Most common malignant tumor of bone overall. Primary sources: breast, prostate, lung, kidney, thyroid. Lesions: breast (mixed), prostate (blastic), lung/kidney/thyroid (lytic). Sites: spine, pelvis, proximal femur/humerus. Investigations: X-ray, MRI, CT chest/abdomen, bone scan/PET. Management: systemic therapy, bisphosphonates/denosumab, prophylactic fixation (Mirel’s >8), radiotherapy, spinal stabilization.
What is the most common source of metastatic bone disease?
Which type of metastatic bone lesion is most commonly associated with prostate cancer?
In which anatomical sites are metastatic bone lesions most commonly found?
Which imaging modality is most sensitive for detecting metastatic lesions from prostate cancer?
What is the Mirels score threshold for recommending prophylactic surgical fixation in metastatic bone disease?
Which of the following primary cancers is most commonly associated with lytic bone metastases?
Which systemic therapy is commonly used for treating metastatic bone disease?
Which of the following is NOT a common complication of metastatic bone disease?
What is the primary treatment approach for lytic lesions in metastatic bone disease?
Which treatment is recommended for renal cell carcinoma bone metastases prior to surgery?
