Most common primary malignant tumor of bone (plasma cell dyscrasia). CRAB features: hyperCalcemia, Renal failure, Anemia, Bone lesions (lytic). X‑ray: punched‑out lytic lesions, diffuse osteopenia, vertebral collapse. Diagnosis: serum/urine electrophoresis (M‑protein), bone marrow plasma cells >10%. Treatment: systemic chemotherapy (bortezomib, lenalidomide, dexamethasone), bisphosphonates, SCT in eligible patients.
What is the most common primary malignant tumor of bone in adults?
Which of the following is NOT a component of the CRAB criteria for diagnosing Multiple Myeloma?
Which imaging modality is recommended as first-line for detecting bone involvement in Multiple Myeloma?
What is the characteristic finding on X-ray for Multiple Myeloma?
Which treatment is primarily used for solitary plasmacytoma?
Which laboratory test is essential for diagnosing Multiple Myeloma?
At what percentage of plasma cells in the bone marrow is Multiple Myeloma diagnosed according to the IMWG criteria?
Which of the following is a poor prognostic factor in Multiple Myeloma?
In terms of skeletal involvement in Multiple Myeloma, which site is most commonly affected?
What is the typical calcium level that indicates hypercalcemia in the context of CRAB criteria?
