High‑grade intramedullary osteosarcoma affects metaphyses of long bones in adolescents (distal femur, proximal tibia, proximal humerus). Workup: **X‑rays**, **MRI with contrast** of entire bone, **CT chest**, and **bone scan/PET‑CT**; labs (ALP, LDH). Biopsy: **planned by treating team** along resection plane to avoid contaminating compartments. Standard treatment: **neoadjuvant chemotherapy (MAP)** → **wide resection** with limb‑salvage reconstruction where feasible → **adjuvant chemotherapy**. Prognostic factors: histologic response to chemo (>90% necrosis), absence of metastasis, negative margins.
What is the most common site of occurrence for high-grade intramedullary osteosarcoma?
Which of the following is NOT a part of the standard workup for suspected osteosarcoma?
What is the standard neoadjuvant chemotherapy regimen for osteosarcoma?
Which laboratory marker is of most value in monitoring osteoblastic activity in osteosarcoma?
What is the most important prognostic factor for osteosarcoma at diagnosis?
Which imaging modality is considered mandatory for local staging of osteosarcoma?
In cases of osteosarcoma, which of the following histological subtypes has the best prognosis?
What is the recommended initial treatment approach for localized osteosarcoma?
Which of the following statements regarding the histological features of osteosarcoma is true?
Which of the following imaging findings is most characteristic of osteosarcoma?
