Osteosarcoma — Workup & Management
High‑grade intramedullary osteosarcoma affects metaphyses of long bones in adolescents (distal femur, proximal tibia, proximal humerus). Workup: **X‑rays**, **MRI with contrast** of entire bone, **CT chest**, and **bone scan/PET‑CT**; labs (ALP, LDH). Biopsy: **planned by treating team** along resection plane to avoid contaminating compartments. Standard treatment: **neoadjuvant chemotherapy (MAP)** → **wide resection** with limb‑salvage reconstruction where feasible → **adjuvant chemotherapy**....
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1Practised by MCQ
10What is the most common site of occurrence for high-grade intramedullary osteosarcoma?
mcqWhich of the following is NOT a part of the standard workup for suspected osteosarcoma?
mcqWhat is the standard neoadjuvant chemotherapy regimen for osteosarcoma?
mcqWhich laboratory marker is of most value in monitoring osteoblastic activity in osteosarcoma?
mcqWhat is the most important prognostic factor for osteosarcoma at diagnosis?
mcqWhich imaging modality is considered mandatory for local staging of osteosarcoma?
mcqIn cases of osteosarcoma, which of the following histological subtypes has the best prognosis?
mcqWhat is the recommended initial treatment approach for localized osteosarcoma?
mcqWhich of the following statements regarding the histological features of osteosarcoma is true?
mcqWhich of the following imaging findings is most characteristic of osteosarcoma?
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