Orthonotes
Orthonotes
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Osteosarcoma — Diagnosis & Treatment

Most common primary malignant bone tumor in adolescents (after myeloma overall). Sites: metaphysis of long bones—distal femur, proximal tibia, proximal humerus. X‑ray: sunburst periosteal reaction, Codman triangle, mixed lytic–sclerotic lesion. Work‑up: MRI for local staging, CT chest for metastasis, bone scan for skip lesions. Treatment: neoadjuvant chemotherapy → wide resection/limb salvage/rotationplasty → adjuvant chemotherapy.