Orthonotes
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Ewing’s Sarcoma — Protocols

Second most common malignant bone tumor in children/adolescents after osteosarcoma. Characterized by t(11;22) → EWS-FLI1 translocation. Common sites: diaphysis of long bones, pelvis, ribs. Onion-skin periosteal reaction on X-ray is classical. Treatment: multi-agent chemotherapy (VDC/IE), surgical resection ± radiotherapy. Overall survival ~70% in localized disease,