Orthonotes
Orthonotes
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Biopsy Principles in MSK Oncology

Biopsy is critical for diagnosis but must follow strict oncological principles. Plan biopsy with final surgery in mind; incision should be longitudinal and in line with resection. Avoid contamination of uninvolved compartments and neurovascular structures. Prefer core needle/incisional biopsy; excisional only for small superficial masses. Send adequate tissue for histopathology, culture, cytogenetics.

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Biopsy is critical for diagnosis but must follow strict oncological principles. Plan biopsy with final surgery in mind; incision should be longitudinal and in line with resection. Avoid contamination of uninvolved compartments and neurovascular structures. Prefer core needle/incisional biopsy; excisional only for small superficial masses. Send adequate tissue for histopathology, culture, cytogenetics.
MCQs

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Question 1

What is the primary objective of planning a biopsy in musculoskeletal oncology?

Question 2

Which imaging modality is recommended to be performed first before a biopsy in suspected sarcoma?

Question 3

According to the Mankin principle, who should ideally perform the biopsy of a suspected sarcoma?

Question 4

What is the most significant risk of a poorly planned biopsy in musculoskeletal oncology?

Question 5

What type of biopsy is preferred for small superficial masses in musculoskeletal oncology?

Question 6

What is the minimum number of passes recommended during a CT-guided core needle biopsy?

Question 7

Which of the following is NOT a reason to avoid contamination during a biopsy?

Question 8

What is one disadvantage of open incisional biopsy compared to core needle biopsy?

Question 9

Why is it crucial to complete all staging imaging before a biopsy in suspected sarcomas?

Question 10

In which case is an excisional biopsy the most appropriate choice?