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Evidence Search

Search reputable indexed orthopaedic literature from multiple scholarly sources, classify the evidence, and link papers directly to wiki topics and cases.

Sources: PubMed, Europe PMC, Crossref

Linking results to Wiki: TB Knee
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Results are classified automatically from source metadata across PubMed, Europe PMC, and Crossref.
PubMed Crossref
PubMed Randomized Controlled Trial Evidence High

High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis : A Randomized Trial With Parallel Preference Arm.

Annals of internal medicine | 2025 | Birmingham TB, Primeau CA, Moyer RF, Bryant DM

[Indexed for MEDLINE] Conflict of interest statement: Disclosures: Disclosure forms are available with the article online. 14. Osteoporos Int. 2025 Dec;36(12):2483-2495. doi: 10.1007/s00198-025-07652-5. Epub 2025 Aug 27. More severe microdamage and micromechanical alterations: altered subchondral bone remodeling in varus knee osteoarthritis with osteoporosis. Zeng ZJ(1), PengPe...

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PubMed Systematic Review / Meta-analysis Evidence High

Safety and effectiveness of intraosseous regional prophylactic antibiotics in total knee arthroplasty: a systematic review and meta-analysis.

Archives of orthopaedic and trauma surgery | 2024 | Yu M, Wei Z, Yang X, Xu Y

[Indexed for MEDLINE] Conflict of interest statement: Declarations Conflict of interest All authors complete the ICMJE Uniform Disclosure Form for Potential Conflicts of Interest. Ethical approval All studies included in this review declared ethical approval. 6. Knee Surg Relat Res. 2022 Jun 20;34(1):30. doi: 10.1186/s43019-022-00158-y. Bone loss in aseptic revision total knee...

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PubMed Randomized Controlled Trial Evidence High

Antibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection.

The New England journal of medicine | 2021 | Bernard L, Arvieux C, Brunschweiler B, Touchais S

[Indexed for MEDLINE] 2. Am J Sports Med. 2026 Jan;54(1):223-229. doi: 10.1177/03635465251357593. Epub 2026 Jan 1. Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians. Mayfield CK(1), Bolia IK(1), Feingold CL(1), Lin EH(1), Liu JN(1), Rick Hatch GF(1), Gamradt SC(1), Weber AE(1). Author information: (1)Keck School of Medicine of USC, Los Angeles,...

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PubMed Narrative Review Evidence Moderate

Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.

The American journal of sports medicine | 2026 | Mayfield CK, Bolia IK, Feingold CL, Lin EH

[Indexed for MEDLINE] Conflict of interest statement: One or more of the authors has declared the following potential conflict of interest or source of funding: J.N.L. has received speaking fees from Stryker and hospitality payments from Innocoll Biotherapeutics. G.R.H. has received consulting fees from Arthrex. S.C.G. has received speaking fees from Arthrex; has received consu...

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PubMed Narrative Review Evidence Moderate

Bone loss in aseptic revision total knee arthroplasty: management and outcomes.

Knee surgery & related research | 2022 | Bieganowski T, Buchalter DB, Singh V, Mercuri JJ

Conflict of interest statement: TB, DB, VS, VA, and JR have nothing to disclose. JM is a paid consultant for Medacta. RS is a paid consultant for Intellijoint and Smith&Nephew; holds IP royalties in Smith&Nephew; and holds stock options in Gauss Surgical, Intellijoint, and PSI. 7. Phytomedicine. 2025 Nov 25;148:157431. doi: 10.1016/j.phymed.2025.157431. Epub 2025 Oct 20. Integr...

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PubMed Original Article Evidence Unclassified

Injury and obesity differentially and synergistically induce dysregulation of synovial immune cells in osteoarthritis.

Annals of the rheumatic diseases | 2025 | Harasymowicz NS, Harissa Z, Rashidi N, Lenz K

[Indexed for MEDLINE] Conflict of interest statement: Competing interests None declared. 4. J Orthop Translat. 2022 Dec 7;38:241-255. doi: 10.1016/j.jot.2022.10.015. eCollection 2023 Jan. Teriparatide ameliorates articular cartilage degradation and aberrant subchondral bone remodeling in DMM mice. Li G(1)(2), Liu S(1)(2), Chen Y(1)(2), Xu H(1)(2), Qi T(1)(2), Xiong A(1)(2), Wan...

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PubMed Original Article Evidence Unclassified

Integrative Metabolomics and Pharmacology Reveal Guzhi Zengsheng Zhitongwan's Mechanism in Knee Osteoarthritis.

Phytomedicine : international journal of phytotherapy and phytopharmacology | 2025 | Zhou Y, Ng L, Chen Z, Qin L

[Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest We declare that all authors have no conflicts of interest that could affect the objectivity of the research. We have fully disclosed any potential conflicts of interest and ensure that these conflicts do not influence the design, execution, or reporting of the study. 8. Medicine (Baltimore)....

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PubMed Original Article Evidence Unclassified

The interleukin-33 receptor (ST2) is a novel therapeutic target to attenuate the progression of hemophilic arthropathy.

Blood | 2025 | Hawerkamp HC, Yeow A, Byrne CM, Chevalier A

[Indexed for MEDLINE] Conflict of interest statement: Conflict-of-interest disclosure: P.L.T., B.M.R., and B.G. are full-time employees of Baxalta Innovations GmbH, a member of the Takeda group of companies; and shareholders of Takeda Pharmaceutical Company Limited when the experiments have been performed. J.S.O. has served on the speakers bureau for Baxter, Bayer, Novo Nordisk...

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PubMed Original Article Evidence Unclassified

More severe microdamage and micromechanical alterations: altered subchondral bone remodeling in varus knee osteoarthritis with osteoporosis.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA | 2025 | Zeng ZJ, PengPeng, Huang CL, Yao FM

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Conflict of interest: None. 15. J Orthop Translat. 2025 Jul 17;54:51-64. doi: 10.1016/j.jot.2025.06.016. eCollection 2025 Sep. Predicting periprosthetic joint Infection: Evaluating supervised machine learning models for clinical application. Dragosloveanu S(1)(2), Vulpe DE(1)(2), Andrei CA(2), Nedelea DG(2), Ga...

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PubMed Original Article Evidence Unclassified

Predicting periprosthetic joint Infection: Evaluating supervised machine learning models for clinical application.

Journal of orthopaedic translation | 2025 | Dragosloveanu S, Vulpe DE, Andrei CA, Nedelea DG

Conflict of interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. 16. NMR Biomed. 2006 Nov;19(7):822-54. doi: 10.1002/nbm.1063. Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis. Eckstein F(1), Burstein D, Link TM....

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PubMed Original Article Evidence Unclassified

Subchondral injection of human umbilical cord mesenchymal stem cells ameliorates knee osteoarthritis by inhibiting osteoblast apoptosis and TGF-beta activity.

Stem cell research & therapy | 2025 | Wu C, Xu H, Wu Z, Huang H

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethics approval and consent to participate: The procedures of this study entitled ‘Subchondral injection of human umbilical cord mesenchymal stem cells ameliorates knee osteoarthritis by inhibiting osteoblast apoptosis and TGF-beta activity’ were approved by the Experimental Animal Ethics Committee of Zhejiang...

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PubMed Original Article Evidence Unclassified

Human Infrapatellar Fat Pad Mesenchymal Stem Cell-derived Extracellular Vesicles Purified by Anion Exchange Chromatography Suppress Osteoarthritis Progression in a Mouse Model.

Clinical orthopaedics and related research | 2024 | Liu Q, Wu J, Wang H, Jia Z

[Indexed for MEDLINE] Conflict of interest statement: Each author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article related to the author or any immediate family members. All ICMJE Conflict of Interes...

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Crossref Journal Article Evidence Unclassified

Total Knee Replacement in a Young Patient with Valgus Knee Osteoarthritis: A Case Report

Journal of Orthopaedic Case Reports | 2024 | Pervez Ahsan, Md. Shafiul Ezaz, Israt Jahan, Nusrat Sharmin Asma

Introduction: Valgus deformity is characterized by an outward angulation of the knee joint. The most common cause of valgus deformity is osteoarthritis (OA), a prevalent progressive joint disease that causes chronic pain and functional limitations. Total knee replacement (TKR) is rarely done in patients with grade-I valgus deformity and young age. To the best of our knowledge,...

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PubMed Original Article Evidence Unclassified

Teriparatide ameliorates articular cartilage degradation and aberrant subchondral bone remodeling in DMM mice.

Journal of orthopaedic translation | 2023 | Li G, Liu S, Chen Y, Xu H

Conflict of interest statement: The authors declare that they have no conflict of interest. 5. Arch Orthop Trauma Surg. 2024 Sep;144(9):4233-4245. doi: 10.1007/s00402-024-05513-0. Epub 2024 Sep 19. Safety and effectiveness of intraosseous regional prophylactic antibiotics in total knee arthroplasty: a systematic review and meta-analysis. Yu M(#)(1), Wei Z(#)(1)(2), Yang X(1), X...

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PubMed Case Report / Series Evidence Low

Tubercular prosthetic joint infection: two case reports and literature review.

Infection | 2018 | Veloci S, Mencarini J, Lagi F, Beltrami G

[Indexed for MEDLINE] 20. Orthop Rev (Pavia). 2024 Apr 3;16:115601. doi: 10.52965/001c.115601. eCollection 2024. Osteoarticular TB specimen yield rates. Large joint analysis at a single centre. Kgagudi MP(1), Hlapolosa T(1), Jingo M(1), Ramokgopa MT(1), Van Den Berg E(2). Author information: (1)Orthopaedic Surgery University of the Witwatersrand. (2)Anatomical Pathology Wits Un...

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PubMed Original Article Evidence Unclassified

Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats.

Arthritis research & therapy | 2022 | Song X, Zhao M, Tang J, Ma T

[Indexed for MEDLINE] Conflict of interest statement: The authors declare that they have no competing interests. 12. Transplant Proc. 2016 Mar;48(2):646-53. doi: 10.1016/j.transproceed.2016.02.049. Post-transplantation Infections in Bolivia. Arze S(1), Arze L(2), Abecia C(2). Author information: (1)Centro Médico Quirurgico Boliviano Belga, Cochabamba, Bolivia. Electronic addres...

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PubMed Narrative Review Evidence Moderate

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis.

NMR in biomedicine | 2006 | Eckstein F, Burstein D, Link TM

[Indexed for MEDLINE] 17. Stem Cell Res Ther. 2025 May 9;16(1):235. doi: 10.1186/s13287-025-04366-7. Subchondral injection of human umbilical cord mesenchymal stem cells ameliorates knee osteoarthritis by inhibiting osteoblast apoptosis and TGF-beta activity. Wu C(#)(1)(2)(3), Xu H(#)(1)(4), Wu Z(#)(2)(5), Huang H(1)(2), Ge Q(1)(4), Xu J(6), Chen J(1)(4), Wang P(1)(4), Yuan W(1...

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PubMed Original Article Evidence Unclassified

bbFISH-ing in the sonication fluid.

Medicine | 2019 | Birlutiu RM, Birlutiu V, Cismasiu RS, Mihalache M

[Indexed for MEDLINE] Conflict of interest statement: The authors have no conflicts of interest to disclose. 9. Blood. 2025 Oct 16;146(16):1979-1990. doi: 10.1182/blood.2024027578. The interleukin-33 receptor (ST2) is a novel therapeutic target to attenuate the progression of hemophilic arthropathy. Hawerkamp HC(1), Yeow A(1), Byrne CM(1), Chevalier A(1), Matarazzo L(1), Lawren...

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PubMed Original Article Evidence Unclassified

Post-transplantation Infections in Bolivia.

Transplantation proceedings | 2016 | Arze S, Arze L, Abecia C

[Indexed for MEDLINE] 13. Ann Intern Med. 2025 Sep;178(9):1238-1248. doi: 10.7326/ANNALS-25-00920. Epub 2025 Jul 29. High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis : A Randomized Trial With Parallel Preference Arm. Birmingham TB(1), Primeau CA(1), Moyer RF(2), Bryant DM(3), Ma J(4), Leitch KM(5), Wirth W(6), Degen R(7), Getgood AM(8), Litchfield RB(7), Willits...

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PubMed Case Report / Series Evidence Low

Arthritis associated with tuberculosis.

Best practice & research. Clinical rheumatology | 2003 | Malaviya AN, Kotwal PP

[Indexed for MEDLINE] 11. Arthritis Res Ther. 2022 Jun 28;24(1):158. doi: 10.1186/s13075-022-02832-8. Dark-light cycle disrupts bone metabolism and suppresses joint deterioration in osteoarthritic rats. Song X(1), Zhao M(1), Tang J(1), Ma T(1), Bai H(1), Wang X(1), Liu L(1), Li T(1), Xu X(1), Sheng X(1), Zhao B(1), Wang Y(1), Wang T(1), Guo Y(1), Zhang X(1), Gao L(2). Author in...

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