bbFISH-ing in the sonication fluid.

Journal and index pages often block iframe embedding. This reader keeps the evidence details in Orthonotes and leaves the source page one click away.

Abstract

[Indexed for MEDLINE] Conflict of interest statement: The authors have no conflicts of interest to disclose. 6. Bone. 2020 Nov;140:115558. doi: 10.1016/j.bone.2020.115558. Epub 2020 Jul 27. Composition and characteristics of trabecular bone in osteoporosis and osteoarthritis. Tamimi I(1), Cortes ARG(2), Sánchez-Siles JM(3), Ackerman JL(4), González-Quevedo D(5), García Á(3), Yaghoubi F(6), Abdallah MN(6), Eimar H(7), Alsheghri A(8), Laurenti M(9), Al-Subaei A(6), Guerado E(10), García-de-Quevedo D(3), Tamimi F(6). Author information: (1)Department of Orthopedic Surgery, Regional University Hospital of Málaga, Spain. Electronic address: i.ahmad.tamimi.sspa@juntadeandalucia.es. (2)Department of Radiology, Massachusetts General Hospital, Charlestown, USA; Department of Dental Surgery, Faculty of Dental Surgery, University of Malta. (3)Department of Orthopedic Surgery, Regional University Hospital of Málaga, Spain. (4)Department of Radiology, Massachusetts General Hospital, Charlestown, USA. (5)Department of Orthopedic Surgery, Regional University Hospital of Málaga, Spain. Electronic address: david.gonzalezq.sspa@juntadeandalucia.es. (6)Faculty of Dentistry, McGill University, Montreal, Canada. (7)Faculty of Medicine and Dentistry, University of Alberta, Canada. (8)Department of Mining and Materials Engineering, McGill University, Montreal, Canada. (9)Faculty of Pharmacy, Complutense University of Madrid, Spain. (10)Faculty of Medicine, University of Málaga, Spain. BACKGROUND: Bone strength depends on multiple factors such as bone density, architecture and composition turnover. However, the role these factors play in osteoporotic fractures is not well understood. PURPOSE: The aim of this study was to analyze trabecular bone architecture, and its crystal and organic composition in humans, by comparing samples taken from patients who had a hip fracture (HF) and individuals with hip osteoarthritis (HOA). METHODS: The study included 31 HF patients and 42 cases of HOA who underwent joint replacement surgery between 1/1/2013 and 31/12/2013. Trabecular bone samples were collected from the femoral heads and analyzed using a dual-energy X-ray absorptiometry, micro-CT, and solid-state high-resolution magic-angle-spinning nuclear magnetic resonance (MAS-NMR) spectroscopy. RESULTS: No differences in proton or phosphorus concentration were found between the two groups using 1H single pulse, 31P single pulse, 31P single pulse with proton decoupling NMR spectroscopy, in hydroxyapatite (HA) c-axis or a-axis crystal length. Bone volume fraction (BV/TV), trabecular number (Tb.N), and bone mineral density (BMD) were higher in the HO group than in the HF group [28.6% ± 10.5 vs 20.3% ± 6.6 (p = 0.026); 2.58 mm-1 ± 1.57 vs 1.5 mm-1 ± 0.79 (p = 0.005); and 0.39 g/cm2 ± 0.10 vs. 0.28 g/cm2 ± 0.05 (p = 0.002), respectively]. The trabecular separation (Tp.Sp) was lower in the HO group 0.42 mm ± 0.23 compared with the HF group 0.58 mm ± 0.27 (p = 0.036). In the HO group, BMD was correlated with BV/TV (r = 0.704, p