Second most common malignant bone tumor in children/adolescents after osteosarcoma. Characterized by t(11;22) → EWS-FLI1 translocation. Common sites: diaphysis of long bones, pelvis, ribs. Onion-skin periosteal reaction on X-ray is classical. Treatment: multi-agent chemotherapy (VDC/IE), surgical resection ± radiotherapy. Overall survival ~70% in localized disease,
What is the male to female ratio generally observed in Ewing's sarcoma?
Which of the following tests is confirmatory for the diagnosis of Ewing's sarcoma?
What is the typical location of Ewing's sarcoma lesions?
Which systemic feature is often elevated in patients with Ewing's sarcoma?
What is the most common age range for the diagnosis of Ewing's sarcoma?
Which of the following translocations is most commonly associated with Ewing's sarcoma?
Which imaging feature is classically associated with Ewing's sarcoma?
What is the overall survival rate for localized Ewing's sarcoma with modern treatment?
Which of the following is a common presenting symptom of Ewing's sarcoma?
In the context of Ewing's sarcoma, what does the acronym PNET stand for?
