High-grade soft tissue sarcoma, often near large joints of extremities (knee, ankle). Affects adolescents and young adults (15–40 years). Histology: biphasic (epithelial + spindle cells) or monophasic; SYT-SSX fusion gene (t[X;18]). Imaging: calcification may be seen on X-ray; MRI shows heterogeneous mass. Treatment: wide excision with radiotherapy; chemotherapy (ifosfamide, doxorubicin) improves survival in advanced cases.
What is the most common age group affected by synovial sarcoma?
Which of the following is the pathognomonic genetic alteration associated with synovial sarcoma?
Which subtype of synovial sarcoma is characterized by both epithelial and spindle cell components?
What is the most common location for synovial sarcoma?
Which imaging modality is most useful in evaluating synovial sarcoma?
In synovial sarcoma, which of the following treatment modalities is considered most effective for localized disease?
Which immunohistochemical marker is highly sensitive and specific for synovial sarcoma?
What is the prognosis for patients with metastatic synovial sarcoma?
What is a characteristic feature of the monophasic subtype of synovial sarcoma?
Which treatment regimen is typically used for advanced synovial sarcoma?
