Focal disorder of accelerated bone turnover: osteoclastic resorption followed by disorganized osteoblastic formation → enlarged, weak, vascular bone. Common sites: pelvis, spine, femur, tibia, skull; often polyostotic; usually age >55. Symptoms: bone pain, deformity (tibia/femur bowing), pathological fractures, skull enlargement, hearing loss; many asymptomatic. Labs: ↑ALP with normal Ca/PO4 (unless immobilization or hyperparathyroidism). Imaging: X‑ray with mixed lytic–sclerotic changes and bone enlargement; bone scan shows extent; CT/MRI for complications. Complications: fracture, deformity/arthritis, cranial neuropathies, high‑output cardiac failure (rare), osteosarcoma (~1%). Treatment: Nitrogen bisphosphonates (zoledronate) for pain, high ALP, or planned surgery; orthopaedic correction for deformity/arthritis.
What is the most common symptom of Paget's disease of bone?
Which of the following imaging findings is characteristic of the mixed phase of Paget's disease?
In Paget's disease, which lab finding is typically elevated?
Which genetic mutation is most commonly associated with familial cases of Paget's disease?
Which of the following bones is least likely to be affected by Paget's disease?
What is a potential rare complication of Paget's disease?
Which treatment is primarily used for managing pain in Paget's disease?
What age group is primarily affected by Paget's disease?
Which of the following is a classic radiological feature of Paget's disease in the skull?
What is the most common demographic group affected by Paget's disease?
