Standard: cefazolin within 60 min before incision (2 g; 3 g if >120 kg). Add vancomycin if MRSA colonized/high prevalence or severe β‑lactam allergy; start 120 min pre‑incision due to infusion time. Redose if procedure >3–4 h or blood loss >1500 mL; discontinue within 24 h for clean cases. Open fractures: start immediately; broaden by Gustilo grade.
What is the recommended timing for administering prophylactic antibiotics before an orthopaedic surgical incision?
Which antibiotic is most commonly used for prophylaxis in orthopaedic surgery?
In which scenario should vancomycin be added to the prophylactic regimen?
What is the recommended duration for discontinuing prophylactic antibiotics in clean cases postoperatively?
For which Gustilo grade of open fracture is the use of a cephalosporin plus an aminoglycoside recommended?
What is a potential complication of antibiotic use that is particularly concerning in orthopaedic surgery?
What should be done if an orthopaedic procedure is expected to last longer than 3–4 hours?
Which of the following organisms is the most common pathogen responsible for surgical site infections in orthopaedic surgery?
For a patient with a severe allergy to penicillin undergoing an orthopaedic procedure, which antibiotic is a suitable alternative?
In the case of open fractures, when should prophylactic antibiotics be administered?
