Multiple Myeloma & Plasmacytoma
Most common primary malignant tumor of bone (plasma cell dyscrasia). CRAB features: hyperCalcemia, Renal failure, Anemia, Bone lesions (lytic). X‑ray: punched‑out lytic lesions, diffuse osteopenia, vertebral collapse. Diagnosis: serum/urine electrophoresis (M‑protein), bone marrow plasma cells >10%. Treatment: systemic chemotherapy (bortezomib, lenalidomide, dexamethasone), bisphosphonates, SCT in eligible patients.
Practised by MCQ
10What is the most common primary malignant tumor of bone in adults?
mcqWhich of the following is NOT a component of the CRAB criteria for diagnosing Multiple Myeloma?
mcqWhich imaging modality is recommended as first-line for detecting bone involvement in Multiple Myeloma?
mcqWhat is the characteristic finding on X-ray for Multiple Myeloma?
mcqWhich treatment is primarily used for solitary plasmacytoma?
mcqWhich laboratory test is essential for diagnosing Multiple Myeloma?
mcqAt what percentage of plasma cells in the bone marrow is Multiple Myeloma diagnosed according to the IMWG crit...
mcqWhich of the following is a poor prognostic factor in Multiple Myeloma?
mcqIn terms of skeletal involvement in Multiple Myeloma, which site is most commonly affected?
mcqWhat is the typical calcium level that indicates hypercalcemia in the context of CRAB criteria?