Bone Grafts and Substitutes
Autograft is gold standard: osteogenic + osteoinductive + osteoconductive (iliac crest). Allograft provides scaffold (osteoconductive) ± growth factors; immune & disease transmission risks minimized by processing. Substitutes: calcium phosphates (HA/TCP), calcium sulfate, bioactive glass; mainly osteoconductive. Biologics: BMP‑2/7, PRP (controversial), bone marrow aspirate concentrate. Applications: nonunion, defects, spinal fusion; match graft biology to defect needs.
Practised by MCQ
10Which of the following graft types is considered the gold standard for bone grafting due to its complete biolo...
mcqWhat is the primary biological mechanism by which autografts promote bone healing?
mcqWhich of the following is a key advantage of using allografts?
mcqWhich synthetic bone substitute is known for its rapid resorption?
mcqWhat is the primary function of bone morphogenetic proteins (BMPs) in bone grafting?
mcqWhat is a significant disadvantage of using autogenous bone grafts?
mcqWhich of the following properties is primarily associated with allografts?
mcqWhat is the primary advantage of synthetic bone substitutes compared to natural bone grafts?
mcqWhich of the following is a potential risk associated with the use of allografts?
mcqIn which clinical scenario is an autogenous cancellous bone graft most commonly utilized?