Evidence Search

Clinical Applicability of Autologous Chondrocyte Implantation for the Treatment of Osteochondral Defects: A Meta-analysis.

Current rheumatology reviews | 2024 | Almohaileb FI, Rasheed Z

[Indexed for MEDLINE] 4. Clin Sports Med. 2010 Apr;29(2):267-82, viii. doi: 10.1016/j.csm.2009.12.004. Rehabilitation after autologous chondrocyte implantation in athletes. Nho SJ(1), Pensak MJ, Seigerman DA, Cole BJ. Author information: (1)Cartilage Restoration Center, Division of Sports Medicine, Department of Orthopedic Surgery, Midwest Orthopaedics at Rush, Rush University...

Operative Treatment of Nonprimary Osteochondral Lesions of the Talus: A Systematic Review.

Orthopaedic journal of sports medicine | 2024 | Correia Cardoso R, Andrade R, Monteiro I, Machado C

Conflict of interest statement: The authors declared that they have no conflicts of interest in the authorship and publication of this contribution. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto. 19. Indian J Orthop. 2021 Jan...

A systematic review of cartilage procedures for unstable osteochondritis dissecans.

The Physician and sportsmedicine | 2023 | Matthews JR, Sonnier JH, Paul RW, Avendano JP

[Indexed for MEDLINE] 9. Adv Exp Med Biol. 2022;1401:23-55. doi: 10.1007/5584_2022_717. Articular Cartilage Regeneration in Veterinary Medicine. Voga M(1), Majdic G(2). Author information: (1)Institute for Preclinical Sciences, University of Ljubljana, Ljubljana, Slovenia. (2)Institute for Preclinical Sciences, University of Ljubljana, Ljubljana, Slovenia. gregor.majdic@vf.uni-...

Efficacy and safety of autologous chondrocyte implantation for osteochondral defects of the talus: a systematic review and meta-analysis.

Archives of orthopaedic and trauma surgery | 2023 | Hu M, Li X, Xu X

[Indexed for MEDLINE] 17. EFORT Open Rev. 2025 Apr 1;10(4):203-212. doi: 10.1530/EOR-2024-0083. Current trends in the treatment of focal cartilage lesions: a comprehensive review. Kutaish H, Klopfenstein A, Obeid Adorisio SN, Tscholl PM, Fucentese S. Focal cartilage lesions refer to localized damage or defects in the cartilage covering joint surfaces, often resulting from traum...

Managing Chondral Lesions: A Literature Review and Evidence-Based Clinical Guidelines.

Indian journal of orthopaedics | 2021 | Banerjee S, Sahanand KS

Conflict of interest statement: Conflict of interestOn behalf of all authors, the corresponding author states that there is no conflict of interest. No financial aid of any nature was obtained from any source for this article. 20. J Orthop Sci. 2024 Jan;29(1):207-216. doi: 10.1016/j.jos.2022.12.001. Epub 2023 Jan 9. Atelocollagen-associated autologous chondrocyte implantation f...

Current trends in the treatment of focal cartilage lesions: a comprehensive review.

EFORT open reviews | 2025 | Kutaish H, Klopfenstein A, Obeid Adorisio SN, Tscholl PM

Conflict of interest statement: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the work reported. 18. Orthop J Sports Med. 2024 Dec 3;12(12):23259671241296434. doi: 10.1177/23259671241296434. eCollection 2024 Dec. Operative Treatment of Nonprimary Osteochondral Lesions of the Talus: A Systematic Review. Corre...

Management of patellofemoral chondral injuries.

Clinics in sports medicine | 2014 | Yanke AB, Wuerz T, Saltzman BM, Butty D

[Indexed for MEDLINE] 3. Curr Rheumatol Rev. 2024;20(3):317-331. doi: 10.2174/0115733971249660231101102757. Clinical Applicability of Autologous Chondrocyte Implantation for the Treatment of Osteochondral Defects: A Meta-analysis. Almohaileb FI(1), Rasheed Z(2). Author information: (1)Department of Family and Community Medicine, College of Medicine, Qassim University, Buraidah,...

Autologous costal chondral transplantation and costa-derived chondrocyte implantation: emerging surgical techniques.

Therapeutic advances in musculoskeletal disease | 2019 | Gao Y, Gao J, Li H, Du D

Conflict of interest statement: Conflict of interest statement: The authors declare that there is no conflict of interest. 2. Clin Sports Med. 2014 Jul;33(3):477-500. doi: 10.1016/j.csm.2014.03.004. Epub 2014 May 17. Management of patellofemoral chondral injuries. Yanke AB(1), Wuerz T(2), Saltzman BM(2), Butty D(2), Cole BJ(2). Author information: (1)Department of Orthopedic Su...

MR imaging of cartilage repair surgery of the knee.

Clinical imaging | 2019 | Liu YW, Tran MD, Skalski MR, Patel DB

[Indexed for MEDLINE] 7. Eur Radiol. 2007 Jan;17(1):103-18. doi: 10.1007/s00330-006-0333-z. Epub 2006 Jun 27. MR imaging of osteochondral grafts and autologous chondrocyte implantation. Trattnig S(1), Millington SA, Szomolanyi P, Marlovits S. Author information: (1)MR Centre of Excellence, Department of Radiology, Medical University of Vienna, Vienna, Austria. siegfried.trattni...

Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC).

Journal of clinical orthopaedics and trauma | 2016 | Huh SW, Shetty AA, Ahmed S, Lee DH

15. J Knee Surg. 2020 Dec;33(12):1187-1200. doi: 10.1055/s-0040-1721053. Epub 2020 Dec 1. Management of Large Focal Chondral and Osteochondral Defects in the Knee. Calcei JG(1), Ray T(2), Sherman SL(2), Farr J(3). Author information: (1)Department of Orthopaedic Surgery, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio. (2)Department of Orthop...

[Problems and complications of surgical techniques for treatment of full-thickness cartilage defects].

Zeitschrift fur Orthopadie und Unfallchirurgie | 2011 | Niemeyer P, Koestler W, Südkamp NP

[Indexed for MEDLINE] 6. Clin Imaging. 2019 Nov-Dec;58:129-139. doi: 10.1016/j.clinimag.2019.07.004. Epub 2019 Jul 11. MR imaging of cartilage repair surgery of the knee. Liu YW(1), Tran MD(2), Skalski MR(3), Patel DB(4), White EA(4), Tomasian A(4), Gross JS(4), Vangsness CT(5), Matcuk GR Jr(6). Author information: (1)Department of Radiology, Harbor-UCLA Medical Center Torrance...

Rehabilitation after autologous chondrocyte implantation in athletes.

Clinics in sports medicine | 2010 | Nho SJ, Pensak MJ, Seigerman DA, Cole BJ

[Indexed for MEDLINE] 5. Z Orthop Unfall. 2011 Jan;149(1):45-51. doi: 10.1055/s-0030-1250104. Epub 2010 Jul 20. [Problems and complications of surgical techniques for treatment of full-thickness cartilage defects]. [Article in German] Niemeyer P(1), Koestler W, Südkamp NP. Author information: (1)Department für Orthopädie und Traumatologie, Klinikum der Albert-Ludwigs-Universitä...

Editorial Commentary: Offloading Patellofemoral Chondral Defects Requires Tailored Tibial Tuberosity Osteotomy Procedures.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association | 2025 | Tanaka MJ

[Indexed for MEDLINE] Conflict of interest statement: Disclosures The author declares the following financial interests/personal relationships which may be considered as potential competing interests: M.J.T. has consulting or advisory relationships with Arthrex, Johnson and Johnson, Vericel, and Verywell Health; is a board member of the American Orthopaedic Society for Sports M...

Autologous chondrocyte implantation, matrix‐induced autologous chondrocyte implantation, osteochondral autograft transplantation and osteochondral allograft improve knee function and pain with considerations for patient and cartilage defects characteristi

Knee Surgery, Sports Traumatology, Arthroscopy | 2025 | Joseph E. Nassar, Grace Guerin, Taidhgin Keel, Raffaella Russo

AbstractPurposePrevious studies have reported on the outcomes of autologous chondrocyte implantation (ACI) versus matrix‐induced ACI (MACI) and microfracture. Specific clinical outcomes of ACI, MACI, osteochondral autograft transplantation (OAT) and osteochondral allograft (OCA) have not been well studied. The purpose of this systematic review and meta‐analysis was to analyze t...

Atelocollagen-associated autologous chondrocyte implantation for the repair of large cartilage defects of the knee: Results at three to seven years.

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association | 2024 | Kaibara T, Kondo E, Matsuoka M, Iwasaki K

[Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare no conflicts of interest associated with this manuscript.

Treatment of osteochondral defects of the talus.

Revue de chirurgie orthopedique et reparatrice de l'appareil moteur | 2008 | van Bergen CJ, de Leeuw PA, van Dijk CN

[Indexed for MEDLINE] 14. J Clin Orthop Trauma. 2016 Jul-Sep;7(3):153-6. doi: 10.1016/j.jcot.2016.05.004. Epub 2016 Jun 16. Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC). Huh SW(1), Shetty AA(2), Ahmed S(2), Lee DH(1), Kim SJ(1). Author information: (1)Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Republic of K...

Socioeconomic Area Deprivation Negatively Impacts Patient-Reported Outcomes Following Autologous Chondrocyte Implantation (ACI) in the Knee

OrthoMedia | 2023

MR imaging of osteochondral grafts and autologous chondrocyte implantation.

European radiology | 2007 | Trattnig S, Millington SA, Szomolanyi P, Marlovits S

[Indexed for MEDLINE] 8. Phys Sportsmed. 2023 Dec;51(6):497-505. doi: 10.1080/00913847.2022.2082262. Epub 2022 May 31. A systematic review of cartilage procedures for unstable osteochondritis dissecans. Matthews JR(1), Sonnier JH(1), Paul RW(1), Avendano JP(2), Saucedo ST(3), Freedman KB(1), Tjoumakaris FP(1). Author information: (1)Division of Sports Medicine, Rothman Orthopae...

Articular Cartilage Regeneration in Veterinary Medicine.

Advances in experimental medicine and biology | 2022 | Voga M, Majdic G

[Indexed for MEDLINE] 10. Cartilage. 2021 Jul;12(3):307-319. doi: 10.1177/1947603519835898. Epub 2019 Mar 17. High-Density Autologous Chondrocyte Implantation as Treatment for Ankle Osteochondral Defects. López-Alcorocho JM(1), Guillén-Vicente I(1), Rodríguez-Iñigo E(1), Navarro R(1), Caballero-Santos R(1), Guillén-Vicente M(1), Casqueiro M(1), Fernández-Jaén TF(1), Sanz F(1),...

Implant system for large osteochondral defects.

Bone | 2022 | Lohfeld S, Curtin W, McHugh PE

Conflict of interest statement: Declaration of competing interest Stefan Lohfeld declares that he has no conflict of interest. William Curtin declares that he has no conflict of interest. Peter McHugh declares that he has no conflict of interest. 12. Arthroscopy. 2025 Jun;41(6):1987-1988. doi: 10.1016/j.arthro.2024.10.012. Epub 2024 Oct 18. Editorial Commentary: Offloading Pate...

Corrigendum to “Differences in Clinical and Functional Outcomes Between Osteochondral Allograft Transplantation and Autologous Chondrocyte Implantation for the Treatment of Focal Articular Cartilage Defects”

Orthopaedic Journal of Sports Medicine | 2022

High-Density Autologous Chondrocyte Implantation as Treatment for Ankle Osteochondral Defects.

Cartilage | 2021 | López-Alcorocho JM, Guillén-Vicente I, Rodríguez-Iñigo E, Navarro R

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. 11. Bone. 2022 Dec;165:116544. doi: 10.1016/j.bone.2022.116544. Epub 2022 Sep 6. Implant system for large osteochondral defects. Lohfeld S(1), Curtin W(...

The Illustrative Overlay Autologous Chondrocyte Implantation (Overlay ACI) Technique for Repair of the Extra-Large Osteochondral Defects

The Illustrative Book of Cartilage Repair | 2021 | Deepak Rajkumar Goyal

Management of Large Focal Chondral and Osteochondral Defects in the Knee.

The journal of knee surgery | 2020 | Calcei JG, Ray T, Sherman SL, Farr J

[Indexed for MEDLINE] Conflict of interest statement: S. L. S. reports personal fees from Joint Restoration Foundation, personal fees from Olympus, personal fees from Smith and Nephew, personal fees from Vericel, personal fees from Arthrex, personal fees from ConMed, personal fees from Flexion Therapeutics, personal fees from Vivorte, outside the submitted work.J. F. reports ot...

Autologous Chondrocyte Implantation “Segmental-Sandwich” Technique for Deep Osteochondral Defects in the Knee: Clinical Outcomes and Correlation With Magnetic Resonance Imaging Findings

Orthopaedic Journal of Sports Medicine | 2019 | Takahiro Ogura, Gergo Merkely, Tim Bryant, Carl S. Winalski

Background: Symptomatic osteochondral defects are difficult to manage, especially in patients with deep (>8-10 mm) empty defects. The restoration of articular congruence is crucial to avoid the progression to osteoarthritis (OA). Purpose: To describe the autologous chondrocyte implantation (ACI) “segmental-sandwich” technique for restoration of the osteochondral unit and to eva...

Comparison of Clinical Outcomes in the Treatment of Patellofemoral Chondral Defects: Autologous Chondrocyte Implantation versus Fresh Osteochondral Allografts

Orthopaedic Journal of Sports Medicine | 2019 | Nirav K. Patel, Vahe Varzhapetyan, Zaira Chaudhry, Hytham S. Salem

Objectives: The complex environment and the extreme stresses of the patellofemoral joint make chondral defects a challenge to treat. Autologous chondrocyte implantation (ACI) and osteochondral allograft transplantation (OCA) have been reported as case series in the patellofemoral joint with mixed results. This study compared the clinical outcomes for ACI and OCA treatments for...

Autologous Chondrocyte Implantation (ACI)

Cartilage Restoration | 2018 | Andreas H. Gomoll, Jack Farr

Cell-seeded Autologous Chondrocyte Implantation (cs-ACI) - A Simplified Implantation Technique with Maintained Clinical Outcomes

Orthopaedic Journal of Sports Medicine | 2016 | Luiz Felipe Morlin Ambra, Amy Phan, Marissa Mastrocola, Andreas H. Gomoll

Objectives: The objective of this study was to investigate whether outcomes and failure rate of a simplified ACI technique (cs-ACI) were comparable to those of the more complicated traditional technique of a chondrocyte suspension injected under membrane cover (cACI). Methods: Patients were treated with cACI prior to February 2010. After this date the senior author switched to...

Paper 240: Autologous Chondrocyte Implantation versus Matrix‐induced Autologous Chondrocyte Implantation for Osteochondral Defects of the Knee Minimum 2 year follow‐up results

Arthroscopy | 2012

Results of collagen covered autologous chondrocyte implantation (ACI-C) for symptomatic osteochondral defects in the knee

Injury Extra | 2007 | S.P. Krishnan, J.A. Skinner, W. Bartlett, R.W.J. Carrington

Treatment of Full-thickness Chondral Defects with Autologous Chondrocyte Implantation

Orthopedic Clinics of North America | 2005 | Scott D. Gillogly, Thomas H. Myers

Rehabilitation after Articular Cartilage Repair Procedures: Osteochondral Autograft Transplantation and Autologous Chondrocyte Implantation

Postsurgical Orthopedic Sports Rehabilitation | 1997 | M REINOLD

Autologous chondrocyte implantation (ACI) in the treatment of early Osteoarthritis (OA)

http://isrctn.org/> | James Richardson