Orthonotes
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Evidence Search

Search reputable indexed orthopaedic literature from multiple scholarly sources, classify the evidence, and link papers directly to wiki topics and cases.

Sources: PubMed, Europe PMC, Crossref

Linking results to Wiki: Ewing’s Sarcoma — Protocols
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Results are classified automatically from source metadata across PubMed, Europe PMC, and Crossref.
PubMed Crossref
PubMed Guideline / Consensus Evidence High

Consensus recommendations for systemic therapies in the management of relapsed Ewing sarcoma: A report from the National Ewing Sarcoma Tumor Board.

Cancer | 2024 | Gupta A, Dietz MS, Riedel RF, Dhir A

[Indexed for MEDLINE] 5. N Engl J Med. 2003 Feb 20;348(8):694-701. doi: 10.1056/NEJMoa020890. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. Grier HE(1), Krailo MD, Tarbell NJ, Link MP, Fryer CJ, Pritchard DJ, Gebhardt MC, Dickman PS, Perlman EJ, Meyers PA, Donaldson SS, Moore S, Rausen AR, Vietti T...

PubMed Guideline / Consensus Evidence High

Consensus recommendations in the management of Ewing sarcoma from the National Ewing Sarcoma Tumor Board.

Cancer | 2023 | Gupta A, Riedel RF, Shah C, Borinstein SC

[Indexed for MEDLINE] 2. Am J Health Syst Pharm. 2010 Oct 1;67(19):1599-605. doi: 10.2146/ajhp090526. Ewing's sarcoma. Karosas AO(1). Author information: (1)Geisinger Medical Center, Danville, PA 17822, USA. akarosas@geisinger.edu PURPOSE: The current treatments of and new therapeutic options for the management of Ewing's sarcoma (ES) are reviewed. SUMMARY: ES is the second mos...

PubMed Randomized Controlled Trial Evidence High

Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial.

Lancet (London, England) | 2022 | Brennan B, Kirton L, Marec-Bérard P, Gaspar N

[Indexed for MEDLINE] Conflict of interest statement: Declaration of interests SS has received honoraria and consulting fees from GSK, Lilly, and Ceridwen Oncology. JM-B reports institutional grants from Adaptimmune, Amgen, AROG, Bayer, Blueprint, Bristol Myers Squibb, Celgene, Daichii-Sankyo, Deciphera, Eisai, FORMA, GSK, IMMIX Biopharma, Karyopharm, Lilly, Nektar, Novartis, P...

PubMed Guideline / Consensus Evidence High

Treatment pathway of bone sarcoma in children, adolescents, and young adults.

Cancer | 2017 | Reed DR, Hayashi M, Wagner L, Binitie O

[Indexed for MEDLINE] 16. Nuklearmedizin. 2017;56(6):233-238. doi: 10.3413/Nukmed-0909-17-07. Epub 2018 Jan 11. Ewing sarcoma during follow-up. [Article in English] Heinemann M, Ranft A, Jürgens H, Langer T, Vieth V, Timmermann B, Weckesser M, Dirksen U, Stegger L. AIM: To evaluate the performance of a prospectively defined follow-up imaging protocol that includes FDG-PET(/CT)...

PubMed Narrative Review Evidence Moderate

Update on the management of BCOR::CCNB3 sarcoma.

Japanese journal of clinical oncology | 2025 | Imanishi J, Sato K, Kikuchi Y, Yamamoto A

[Indexed for MEDLINE] 15. Cancer. 2017 Jun 15;123(12):2206-2218. doi: 10.1002/cncr.30589. Epub 2017 Mar 21. Treatment pathway of bone sarcoma in children, adolescents, and young adults. Reed DR(1)(2)(3), Hayashi M(4), Wagner L(5), Binitie O(1)(3)(6), Steppan DA(4), Brohl AS(1)(2), Shinohara ET(7), Bridge JA(8), Loeb DM(4), Borinstein SC(9), Isakoff MS(10). Author information: (...

PubMed Narrative Review Evidence Moderate

Small round cell sarcomas.

Nature reviews. Disease primers | 2022 | Cidre-Aranaz F, Watson S, Amatruda JF, Nakamura T

[Indexed for MEDLINE] 7. Gan To Kagaku Ryoho. 2007 Feb;34(2):175-80. [Ewing sarcoma]. [Article in Japanese] Hamanoue S(1), Makimoto A. Author information: (1)Division of Pediatrics, National Cancer Center Hospital. Ewing sarcoma is the second most frequent primary bone cancer affecting children or young adults. Advances in molecular biology have revealed common chromosomal tran...

PubMed Narrative Review Evidence Moderate

Advances in immune checkpoint inhibitors for bone sarcoma therapy.

Journal of bone oncology | 2019 | Thanindratarn P, Dean DC, Nelson SD, Hornicek FJ

18. Curr Treat Options Oncol. 2009 Apr;10(1-2):126-40. doi: 10.1007/s11864-009-0104-6. Epub 2009 Jun 17. Ewing's sarcoma: standard and experimental treatment options. Subbiah V(1), Anderson P, Lazar AJ, Burdett E, Raymond K, Ludwig JA. Author information: (1)Department of Sarcoma Medical Oncology, Division of Cancer Medicine, Labortory of Sarcoma Molecular Therapeutics, M.D. An...

PubMed Narrative Review Evidence Moderate

Chemotherapy for bone sarcomas in adults: the MD anderson experience.

American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting | 2015 | Benjamin RS, Wagner MJ, Livingston JA, Ravi V

[Indexed for MEDLINE] 20. Bull Cancer. 2025 Jun;112(6):601-610. doi: 10.1016/j.bulcan.2024.03.010. Epub 2025 Apr 10. [Recurrent or refractory Osteosarcoma and Ewing sarcoma-French guidelines from the FSG/NETSARC and GroupOs groups]. [Article in French] Brahmi M(1), Toulmonde M(2), Winter S(3), De Percin S(4), Valentin T(5), Corradini N(6), Gantzer J(7), Marec-Berard P(6), Gouin...

PubMed Randomized Controlled Trial Evidence High

Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone.

The New England journal of medicine | 2003 | Grier HE, Krailo MD, Tarbell NJ, Link MP

[Indexed for MEDLINE] 6. Nat Rev Dis Primers. 2022 Oct 6;8(1):66. doi: 10.1038/s41572-022-00393-3. Small round cell sarcomas. Cidre-Aranaz F(1)(2), Watson S(3)(4), Amatruda JF(5)(6), Nakamura T(7), Delattre O(4), de Alava E(8)(9), Dirksen U(10), Grünewald TGP(11)(12)(13). Author information: (1)Division of Translational Paediatric Sarcoma Research, German Cancer Research Center...

PubMed Narrative Review Evidence Moderate

Ewing's sarcoma.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists | 2010 | Karosas AO

[Indexed for MEDLINE] 3. Lancet. 2022 Oct 29;400(10362):1513-1521. doi: 10.1016/S0140-6736(22)01790-1. Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label, randomised, phase 3 trial. Brennan B(1), Kirton L(2), Marec-Bérard P(3), Gaspar N(4), Laurence V(5), Martín-Broto J(6), Sastre A(7), Gelderblom H(8), Owens C(9), Fen...

PubMed Narrative Review Evidence Moderate

Ewing's sarcoma: standard and experimental treatment options.

Current treatment options in oncology | 2009 | Subbiah V, Anderson P, Lazar AJ, Burdett E

[Indexed for MEDLINE] 19. Am Soc Clin Oncol Educ Book. 2015:e656-60. doi: 10.14694/EdBook_AM.2015.35.e656. Chemotherapy for bone sarcomas in adults: the MD anderson experience. Benjamin RS(1), Wagner MJ(1), Livingston JA(1), Ravi V(1), Patel SR(1). Author information: (1)From the Department of Sarcoma Medical Oncology, Division of Cancer Medicine, The University of Texas MD And...

PubMed Original Article Evidence Unclassified

Modeling Ewing Sarcoma Lung Metastasis.

Current protocols | 2023 | Dasgupta A, Kurenbekova L, Patel TD, Rajapakshe K

[Indexed for MEDLINE] Conflict of interest statement: CONFLICT OF INTEREST STATEMENT: No conflict of interest to declare. 10. J Surg Oncol. 1993 Mar;52(3):188-92. doi: 10.1002/jso.2930520315. Ewing's sarcoma. Iyer RS(1), Rao SR, Gurjal A, Nair CN, Pai SK, Kurkure PA, Pande SC, Advani SH. Author information: (1)Department of Medical Oncology, Tata Memorial Hospital, Bombay, Indi...

PubMed Narrative Review Evidence Moderate

Sarcoma and the spinal column.

Neurosurgery clinics of North America | 2008 | Wang VY, Potts M, Chou D

[Indexed for MEDLINE] 12. Pediatr Med Chir. 1984 Mar-Apr;6(2):201-8. [Bone tumors]. [Article in Italian] Madon E, Grazia G, Brach Del Prever A. In this paper are briefly reasumed clinical features and diagnostic procedures for bone tumors. More closely are examinated osteogenic sarcoma and Ewing's sarcoma in childhood and evaluated therapeutical means comparing the achieved res...

Crossref Journal Article Evidence Unclassified

Experience-Based Opioid-Sparing Orthopedic Surgical Protocols

Journal of Orthopaedic Experience & Innovation | 2021 | Cassie Chin, Scott Sigman

Specific protocols have been established for each of the time windows involved in the perioperative surgical experience. We use a combination of medications, medical devices, local and regional anesthetics to minimize pain while trying to avoid Opioids.

PubMed Original Article Evidence Unclassified

Ewing sarcoma during follow-up.

Nuklearmedizin. Nuclear medicine | 2017 | Heinemann M, Ranft A, Jürgens H, Langer T

[Indexed for MEDLINE] Conflict of interest statement: The authors have nothing to disclose. 17. J Bone Oncol. 2019 Jan 29;15:100221. doi: 10.1016/j.jbo.2019.100221. eCollection 2019 Apr. Advances in immune checkpoint inhibitors for bone sarcoma therapy. Thanindratarn P(1)(2), Dean DC(1), Nelson SD(3), Hornicek FJ(1), Duan Z(1). Author information: (1)Department of Orthopedic Su...

PubMed Original Article Evidence Unclassified

[Ewing sarcoma].

Gan to kagaku ryoho. Cancer & chemotherapy | 2007 | Hamanoue S, Makimoto A

[Indexed for MEDLINE] 8. Gan To Kagaku Ryoho. 2004 Mar;31(3):346-50. [Ewing's sarcoma]. [Article in Japanese] Goto T(1), Hozumi T, Kondo T. Author information: (1)Dept. of Orthopaedic Surgery and Musculoskeletal Oncology, Tokyo Metropolitan Komagome Hospital, 3-18-22 Hon-Komagome, Bunkyo-ku, Tokyo 113-8677, Japan. Ewing's sarcomas account for 6.8% of all primary malignant bone...

PubMed Original Article Evidence Unclassified

[Ewing's sarcoma].

Gan to kagaku ryoho. Cancer & chemotherapy | 2004 | Goto T, Hozumi T, Kondo T

[Indexed for MEDLINE] 9. Curr Protoc. 2023 Feb;3(2):e670. doi: 10.1002/cpz1.670. Modeling Ewing Sarcoma Lung Metastasis. Dasgupta A(1), Kurenbekova L(1), Patel TD(1), Rajapakshe K(2), Ghosal G(3), Nirala B(1), Coarfa C(4)(5), Yustein J(1). Author information: (1)Texas Children's Cancer and Hematology Centers and The Faris D. Virani Ewing Sarcoma Center, Baylor College of Medici...

PubMed Original Article Evidence Unclassified

Extraskeletal Ewing's sarcoma.

Cancer | 1999 | Ahmad R, Mayol BR, Davis M, Rougraff BT

[Indexed for MEDLINE] 14. Jpn J Clin Oncol. 2025 Oct 7;55(10):1097-1104. doi: 10.1093/jjco/hyaf111. Update on the management of BCOR::CCNB3 sarcoma. Imanishi J(1), Sato K(1), Kikuchi Y(2), Yamamoto A(3), Watabe S(2), Matsuyama T(1), Sato C(3), Kobayashi H(4), Kawano H(1). Author information: (1)Department of Orthopaedic Surgery, Teikyo University School of Medicine, 2-11-1 Kaga...

PubMed Original Article Evidence Unclassified

Ewing's sarcoma.

Journal of surgical oncology | 1993 | Iyer RS, Rao SR, Gurjal A, Nair CN

[Indexed for MEDLINE] 11. Neurosurg Clin N Am. 2008 Jan;19(1):71-80. doi: 10.1016/j.nec.2007.10.001. Sarcoma and the spinal column. Wang VY(1), Potts M, Chou D. Author information: (1)Department of Neurological Surgery, University of California, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143-0112, USA. Primary sarcomas are rare in the spine. Common primary sarcomas in...

PubMed Original Article Evidence Unclassified

[Bone tumors].

La Pediatria medica e chirurgica : Medical and surgical pediatrics | 1984 | Madon E, Grazia G, Brach Del Prever A

[Indexed for MEDLINE] 13. Cancer. 1999 Feb 1;85(3):725-31. Extraskeletal Ewing's sarcoma. Ahmad R(1), Mayol BR, Davis M, Rougraff BT. Author information: (1)Department of Orthopaedics, Indiana University School of Medicine, Indianapolis 46202, USA. BACKGROUND: Ewing's sarcoma usually is identified as a primary malignancy of bone affecting children and young adults. Extraskeleta...