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Evidence Search

Search reputable indexed orthopaedic literature from multiple scholarly sources, classify the evidence, and link papers directly to wiki topics and cases.

Sources: PubMed, Europe PMC, Crossref

Linking results to Wiki: Pathological Fractures — Workup
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Results are classified automatically from source metadata across PubMed, Europe PMC, and Crossref.
PubMed Crossref
PubMed Guideline / Consensus Evidence High

Bone biopsy practice patterns across Europe: the European renal osteodystrophy initiative-a position paper.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association | 2017 | Evenepoel P, D'Haese P, Bacchetta J, Cannata-Andia J

[Indexed for MEDLINE] 17. Clin Orthop Relat Res. 2005 Mar;(432):267-71. doi: 10.1097/01.blo.0000150104.82757.4a. Lymphoma masquerading as infection. Blum YC(1), Esterhai JL, Esmail AN, Lackman RD, Donthineni-Rao R. Author information: (1)Department of Orthopaedic Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA. Yossef613@aol.com Duri...

PubMed Narrative Review Evidence Moderate

Pathological Fractures in Benign Bone Lesions - Diagnosis and Therapy.

Zeitschrift fur Orthopadie und Unfallchirurgie | 2024 | Spodeck D, Guder W, Streitbürger A, Dudda M

[Indexed for MEDLINE] Conflict of interest statement: J. Hardes und A. Streitbürger weisen auf folgende Beziehung hin: Forschungsunterstützung durch die Firma Implantcast, Buxtehude. D. Spodeck, W.Guder,M.Nottrott, L.Podleska,und M.Dudda geben an, dass kein Interessenkonflikt besteht. 5. JBJS Rev. 2023 Jan 10;11(1). doi: 10.2106/JBJS.RVW.22.00166. eCollection 2023 Jan 1. Team A...

PubMed Cohort / Comparative Study Evidence Moderate

Predictors for pathological bone fractures in children undergoing liver transplantation: A retrospective cohort study.

Pediatric transplantation | 2024 | Astolfi D, Rock N, Ceroni D, Wildhaber BE

[Indexed for MEDLINE] 15. Injury. 2015 Oct;46(10):1891-9. doi: 10.1016/j.injury.2015.07.028. Epub 2015 Jul 29. The investigation and management of suspected malignant pathological fractures: a review for the general orthopaedic surgeon. Bryson DJ(1), Wicks L(2), Ashford RU(3). Author information: (1)Department of Orthopaedics, Nottingham University Hospitals NHS Trust, Queen's...

PubMed Narrative Review Evidence Moderate

Osteoporosis in children and adolescents: when to suspect and how to diagnose it.

European journal of pediatrics | 2022 | Ciancia S, van Rijn RR, Högler W, Appelman-Dijkstra NM

[Indexed for MEDLINE] Conflict of interest statement: The authors have no conflict of interests to declare. 8. Med Pharm Rep. 2022 Oct;95(4):377-384. doi: 10.15386/mpr-2215. Epub 2022 Oct 27. Modern imaging techniques for monitoring patients with multiple myeloma. Pop VS(1), Tomoaia G(2)(3), Parvu A(1). Author information: (1)Hematology Department, Iuliu Hatieganu University of...

PubMed Narrative Review Evidence Moderate

Modern imaging techniques for monitoring patients with multiple myeloma.

Medicine and pharmacy reports | 2022 | Pop VS, Tomoaia G, Parvu A

9. Instr Course Lect. 2021;70:453-464. Pediatric Tumor Management: Current and Controversial. Thacker MM, Binitie OT, Lindberg AW, Arkader A. Bone and soft-tissue tumors are common in the pediatric population. It is important to be familiar with the appropriate workup, principles of biopsy, differences between unicameral and aneurysmal bone cysts, and principles of managing pat...

PubMed Narrative Review Evidence Moderate

Management of Long Bones Metastatic Disease: Concepts That We All Know but Not Always Remember.

Orthopedic research and reviews | 2022 | Gonzalez MR, Bryce-Alberti M, Pretell-Mazzini J

Conflict of interest statement: All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. No author involved in the writing of this manuscript receives any funding from industry, holds research grants, or has a conflic...

PubMed Narrative Review Evidence Moderate

[Oncologic aspects in treatment of pathologic fractures].

Der Unfallchirurg | 2021 | Eggers H, Wichmann J, Omar M, Länger F

[Indexed for MEDLINE] 13. Curr Opin Pediatr. 2012 Feb;24(1):46-9. doi: 10.1097/MOP.0b013e32834ec8eb. Vitamin D deficiency: a paediatric orthopaedic perspective. Clarke NM(1), Page JE. Author information: (1)University Hospital Southampton, NHS Foundation Trust Southampton University Hospitals, Southampton General Hospital, Southampton, Hampshire, UK. ortho@soton.ac.uk PURPOSE O...

PubMed Narrative Review Evidence Moderate

[Radiological aspects in the diagnostics of pathological fractures].

Der Unfallchirurg | 2021 | von Falck C, Omar M

[Indexed for MEDLINE] 20. EFORT Open Rev. 2017 Mar 13;1(5):136-145. doi: 10.1302/2058-5241.1.000008. eCollection 2016 May. Treatment of pathological fractures of the long bones. Willeumier JJ(1), van der Linden YM(1), van de Sande MAJ(1), Dijkstra PDS(1). Author information: (1)Department of Orthopaedics, Leiden University Medical Centre, The Netherlands. Bone metastases of the...

PubMed Narrative Review Evidence Moderate

[Radiologic diagnosis of pathologic fractures].

Der Radiologe | 2020 | Wuennemann F, Kintzelé L, Weber MA, Kauczor HU

[Indexed for MEDLINE] 4. Z Orthop Unfall. 2024 Feb;162(1):69-78. doi: 10.1055/a-1850-2540. Epub 2022 Jul 26. Pathological Fractures in Benign Bone Lesions - Diagnosis and Therapy. [Article in English, German; Abstract available in German from the publisher] Spodeck D(1), Guder W(2), Streitbürger A(2), Dudda M(3)(1), Podleska LE(2), Nottrott M(2), Hardes J(2). Author information...

PubMed Narrative Review Evidence Moderate

[Management of osseous complications in multiple myeloma].

Der Internist | 2019 | Zarghooni K, Hopf S, Eysel P

[Indexed for MEDLINE] 19. Unfallchirurg. 2021 Sep;124(9):695-703. doi: 10.1007/s00113-021-01067-7. Epub 2021 Jul 29. [Radiological aspects in the diagnostics of pathological fractures]. [Article in German; Abstract available in German from the publisher] von Falck C(1), Omar M(2). Author information: (1)Institut für Diagnostische und Interventionelle Radiologie, Medizinische Ho...

PubMed Narrative Review Evidence Moderate

Myeloma bone and extra-medullary disease: Role of PET/CT and other whole-body imaging techniques.

Critical reviews in oncology/hematology | 2016 | Rubini G, Niccoli-Asabella A, Ferrari C, Racanelli V

[Indexed for MEDLINE] 7. Eur J Pediatr. 2022 Jul;181(7):2549-2561. doi: 10.1007/s00431-022-04455-2. Epub 2022 Apr 6. Osteoporosis in children and adolescents: when to suspect and how to diagnose it. Ciancia S(1), van Rijn RR(2), Högler W(3), Appelman-Dijkstra NM(4), Boot AM(5), Sas TCJ(6)(7), Renes JS(6). Author information: (1)Department of Pediatrics, Subdivision of Endocrino...

PubMed Narrative Review Evidence Moderate

Bone metastases of unknown origin: epidemiology and principles of management.

Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology | 2015 | Piccioli A, Maccauro G, Spinelli MS, Biagini R

[Indexed for MEDLINE] 11. Orthop Res Rev. 2022 Nov 10;14:393-406. doi: 10.2147/ORR.S379603. eCollection 2022. Management of Long Bones Metastatic Disease: Concepts That We All Know but Not Always Remember. Gonzalez MR(1), Bryce-Alberti M(1), Pretell-Mazzini J(2). Author information: (1)Facultad de Medicina Universidad Peruana Cayetano Heredia, Lima, Peru. (2)Miami Cancer Instit...

PubMed Narrative Review Evidence Moderate

The investigation and management of suspected malignant pathological fractures: a review for the general orthopaedic surgeon.

Injury | 2015 | Bryson DJ, Wicks L, Ashford RU

[Indexed for MEDLINE] 16. Nephrol Dial Transplant. 2017 Oct 1;32(10):1608-1613. doi: 10.1093/ndt/gfw468. Bone biopsy practice patterns across Europe: the European renal osteodystrophy initiative-a position paper. Evenepoel P(1), D'Haese P(2), Bacchetta J(3), Cannata-Andia J(4), Ferreira A(5), Haarhaus M(6), Mazzaferro S(7), Lafage Proust MH(8), Salam S(9), Spasovski G(10), Cozz...

PubMed Case Report / Series Evidence Low

Multidisciplinary team approach for CKD-associated osteoporosis.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association | 2024 | Hansen D, Jørgensen HS, Andersen TL, Ferreira AC

[Indexed for MEDLINE] Conflict of interest statement: D.H. reports research grant from Vifor Pharma and Gedeon Richter and consultancy fees and lecture fees from UCB Nordic, GSK and AstraZeneca. A.C.F. reports lecture fees from Vifor and AstraZeneca. R.J. received fees as site PI in a pharmacy-initiated study (SHP634-401) of Takeda. S.K. reports consultancy fees from Vifor Phar...

PubMed Narrative Review Evidence Moderate

Vitamin D deficiency: a paediatric orthopaedic perspective.

Current opinion in pediatrics | 2012 | Clarke NM, Page JE

[Indexed for MEDLINE] 14. Pediatr Transplant. 2024 May;28(3):e14755. doi: 10.1111/petr.14755. Predictors for pathological bone fractures in children undergoing liver transplantation: A retrospective cohort study. Astolfi D(1), Rock N(1)(2), Ceroni D(3), Wildhaber BE(1)(4). Author information: (1)Department of Pediatrics, Gynecology, and Obstetrics, Swiss Pediatric Liver Center,...

Crossref Journal Article Evidence Unclassified

Undiagnosed Chronic Kidney Disease in a Child With Fractures Presenting to a Pediatric Orthopedic Clinic

Orthopaedic Nursing | 2026 | Cynthia T. Thompson

Pediatric fractures that present without identified trauma can present a challenge to the nurse practitioner in the orthopedic clinic. Etiologies range from nonaccidental trauma to genetic and metabolic diagnoses that may have been previously undetected. It is imperative that the orthopedic nurse practitioner exercise critical thinking to recognize the potential for underlying...

Crossref Journal Article Evidence Unclassified

Pathological Fractures Around the Hip: Approach to Diagnosis and Management

Nepal Orthopedic Association Journal | 2025 | Rishi Ram Poudel

Pathological fractures due to metastatic disease are common around the hip (proximal femur and acetabulum) and represent an escalating concern in musculoskeletal oncology. These fractures should not be fixed straight away and management should focus on comprehensive clinical, laboratory, imaging workup and biopsy, and treatment plan should be tailored and personalized after inp...

Crossref Journal Article Evidence Unclassified

Treatment of Bilateral Distal Femoral Shaft Fractures in a Paraplegic Patient with Intramedullary Nailing: A Case Report

Journal of Orthopaedic Case Reports | 2025 | Ernesto S Quinto Jr., Brendan J Liakos, William L Pistel

Introduction: Lower extremity fractures are a frequent complication in patients with chronic spinal cord injury due to significant bone mineral density loss and altered bone metabolism. While non-operative management has traditionally been favored, advances in surgical techniques have expanded treatment options, including intramedullary nailing and plate fixation. However, the...

PubMed Original Article Evidence Unclassified

Team Approach: Management of Pathologic Fractures.

JBJS reviews | 2023 | Hammad A, Ahmed O, Connell PP, Olson D

[Indexed for MEDLINE] Conflict of interest statement: Disclosure: The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article (http://links.lww.com/JBJSREV/A892). 6. Crit Rev Oncol Hematol. 2016 May;101:169-83. doi: 10.1016/j.critrevonc.2016.03.006. Epub 2016 Mar 5. Myeloma bone and extra-medullary disease: Role of PET/CT and othe...

PubMed Original Article Evidence Unclassified

Pediatric Tumor Management: Current and Controversial.

Instructional course lectures | 2021 | Thacker MM, Binitie OT, Lindberg AW, Arkader A

[Indexed for MEDLINE] 10. J Orthop Traumatol. 2015 Jun;16(2):81-6. doi: 10.1007/s10195-015-0344-0. Epub 2015 Mar 1. Bone metastases of unknown origin: epidemiology and principles of management. Piccioli A(1), Maccauro G, Spinelli MS, Biagini R, Rossi B. Author information: (1)Oncologic Center, "Palazzo Baleani", Teaching Hospital Policlinico Umberto I, Rome, Italy. Metastases a...

Crossref Journal Article Evidence Unclassified

Outcome of percutaneous locked plating of extra-articular distal tibial metaphyseal fractures

Hong Kong Journal of Orthopaedic Research | 2021 | Yasser Youssef Abed, Mohamed Arafa

Introduction: Management of fractures involving the distal tibial metaphysis is one of the most challenging and controversial issue due to poor soft tissue envelop. Multiple different fixation modalities are available with different outcome. Percutaneous plating of the distal tibia fracture is gaining more popularity due to minimal interruption of the fracture biology and favor...

PubMed Narrative Review Evidence Moderate

Osteoporosis. Definition and clinical presentation.

Spine | 1997 | Glaser DL, Kaplan FS

[Indexed for MEDLINE] 2. Nephrol Dial Transplant. 2024 Dec 20;40(1):48-59. doi: 10.1093/ndt/gfae197. Multidisciplinary team approach for CKD-associated osteoporosis. Hansen D(1)(2), Jørgensen HS(3)(4), Andersen TL(5)(6)(7)(8), Ferreira AC(9)(10), Ferreira A(9)(10), de Jongh R(11)(12), Keronen S(13), Kröger H(14)(15), Lafage-Proust MH(16), Martola L(13), Poole KES(17), Tong X(14...

Crossref Scholarly Work Evidence Unclassified

Pathological fractures

Oxford Medicine Online | 2011 | D.E. Porter

♦ Pathological fractures should be recognized before treatment, but often are not.♦ If solitary and potentially malignant, pathological fractures should be investigated prior to treatment.♦ Inappropriate management may compromise outcome.♦ Maximize patient fitness for surgery.♦ Preoperative assessment to look for other tumours e.g. CT scan of chest and abdomen.♦ Biopsy if possi...

PubMed Case Report / Series Evidence Low

Lymphoma masquerading as infection.

Clinical orthopaedics and related research | 2005 | Blum YC, Esterhai JL, Esmail AN, Lackman RD

[Indexed for MEDLINE] 18. Internist (Berl). 2019 Jan;60(1):42-48. doi: 10.1007/s00108-018-0530-2. [Management of osseous complications in multiple myeloma]. [Article in German] Zarghooni K(1), Hopf S(2), Eysel P(2). Author information: (1)Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland. kourosh.zarghooni@uk-ko...