Surgical Outcomes After Limb-Sparing Resection and Reconstruction for Pelvic Sarcoma: A Systematic Review.

Journal and index pages often block iframe embedding. This reader keeps the evidence details in Orthonotes and leaves the source page one click away.

Abstract

[Indexed for MEDLINE] 17. Front Immunol. 2024 Aug 15;15:1416068. doi: 10.3389/fimmu.2024.1416068. eCollection 2024. Prognostic and clinicopathological value of systemic immune-inflammation index in patients with osteosarcoma: a meta-analysis. Wang X(1), Wu Z(2), Zhang Z(1), Jiang Z(3). Author information: (1)Clinical Laboratory, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, China. (2)Clinical Laboratory, Nanxun District Hospital of Traditional Chinese Medicine, Huzhou, Zhejiang, China. (3)Clinical Laboratory, People's Hospital of Anji, Huzhou, Zhejiang, China. BACKGROUND: The efficiency of systemic immune-inflammation index (SII) in predicting prognosis of osteosarcoma (OSA) patients has been extensively analyzed, but no consistent findings are obtained. Therefore, this meta-analysis focused on identifying the precise prognostic value of SII for OSA. METHODS: We comprehensively searched electronic databases of PubMed, Embase, Web of Science, Cochrane Library, and China National Knowledge Infrastructure (CNKI) from inception to 24 February, 2024. Meanwhile, the efficiency of SII in predicting prognosis of OSA was evaluated by calculating pooled hazard ratios (HRs) as well as 95% confidence intervals (CIs). Additionally, the correlation of SII with the OSA clinicopathological characteristics was analyzed based on pooled odds ratios (ORs) and 95%CIs. RESULTS: Six studies with 1015 cases were enrolled into this work. According to the combined data, the higher SII was markedly related to poor overall survival (OS) (HR=2.01, 95%CI=1.30-3.09, p=0.002) and Enneking stage III (OR=2.21, 95%CI=1.11-4.39, p=0.024) of patients with OSA. Nonetheless, SII was not significantly related to gender, age, pathological fracture, tumor size, tumor location, tumor differentiation, and metastasis in patients with OSA. CONCLUSIONS: In summary, the higher SII is markedly related to poor OS and advanced Enneking stage in OSA patients. SYSTEMATIC REVIEW REGISTRATION: https://inplasy.com/inplasy-2024-7-0107/, identifier INPLASY202470107. Copyright © 2024 Wang, Wu, Zhang and Jiang. DOI: 10.3389/fimmu.2024.1416068 PMCID: PMC11357927