Primary bone tumors of the spine. Terminology and surgical staging.

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Abstract

[Indexed for MEDLINE] 16. J Orthop Res. 2019 Jan;37(1):258-264. doi: 10.1002/jor.24143. Epub 2018 Oct 9. Pre-Operative chemotherapy response assessed by contrast-enhanced MRI can predict the prognosis of Enneking surgical margins in patients with osteosarcoma. He F(1), Qin L(2), Bao Q(1), Zang S(1), He Q(1), Qiu S(1)(3)(4), Shen Y(1)(3), Zhang W(1)(3). Author information: (1)Department of Orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. (2)Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. (3)Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. (4)Bone and Mineral Research Laboratory, Henry Ford Hospital, Detroit, Michigan. The method used to evaluate the response of osteosarcoma to preoperative chemotherapy before specimen resection is still unclear. The purpose of this study was to identify factors that contribute to overall survival (OS) and to discuss their roles in making a decision regarding Enneking surgical margins. Patients (109) with pathologically confirmed Enneking stage IIB osteosarcoma were retrospectively analyzed. Univariate and multivariate survival analyses were performed. Patient characteristics and chemotherapy-induced contrast-enhanced MRI changes were considered as potential factors. Changes in the tumor volume and the relative necrosis ratio measured by MRI were independent risk factors predicting the OS of patients who underwent limb-salvage surgery. For those in whom the tumor volume had decreased (VolRatio