Evaluation of the factors affecting survival and local recurrence in thigh soft tissue sarcomas.

Journal and index pages often block iframe embedding. This reader keeps the evidence details in Orthonotes and leaves the source page one click away.

Abstract

[Indexed for MEDLINE] Conflict of interest statement: Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article. 8. J Clin Lab Anal. 2021 Nov;35(11):e23987. doi: 10.1002/jcla.23987. Epub 2021 Sep 20. Circular RNA MTO1 intercorrelates with microRNA-630, both associate with Enneking stage and/or pathological fracture as well as prognosis in osteosarcoma patients. Shi Z(1), Wen Y(2), Zhang S(3), Cheng X(4). Author information: (1)Hand and Foot Surgery, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, China. (2)Emergency Department, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, China. (3)Department of Anesthesiology, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, China. (4)Department of Gynaecology, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, China. OBJECTIVE: Circular RNA-mitochondrial tRNA translation optimization 1 (circ-MTO1) not only involves in bioprocess of various cancers, but also regulates osteosarcoma progression by regulating microRNA-630 (miR-630). However, the clinical role of circ-MTO1 and miR-630 in osteosarcoma is still obscure. This study aimed to assess the correlation of circ-MTO1 and miR-630 with disease features and prognosis and to explore their association with each other in osteosarcoma patients. METHODS: Forty-four osteosarcoma patients who received neoadjuvant chemotherapy to surgical resection were analyzed in this retrospective study. Then, circ-MTO1 and miR-630 expressions were evaluated in tumor and adjacent non-tumor specimens by reverse transcription quantitative polymerase chain reaction. RESULTS: Circ-MTO1 was lower in tumor than in non-tumor tissues (p