KPNA2 promotes osteosarcoma progression by regulating the alternative splicing of DDX3X mediated by YBX1.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Competing interests: LC, KJ, YY, YP, XC, QP, WY, ZZ, ZS, and WW report no conflicts of interest. VT BA reports research grants from Polaris, Pfizer, Merck, Tracon Pharma, GlaxoSmithKline; consulting fees from Bayer, Cytokinetics Inc., Deciphera Pharmaceuticals, Daiichi Sankyo, EcoR1, Advenchen, Putnam, Salarius Pharmaceuticals, Boxer Capital LLC, Acuta Capital Partners LLC, Aadi Biosciences, Race Oncology Limited, Hinge Bio, Inc., and Kronos Bio, Inc.; honoraria for educational talks from Iteration Therapeutics, Inc. and Total Health Conference; fees for participation in Data/Safety Advisory Boards for Apexigen, Daiichi Sankyo, Epizyme, Bayer, PTC Therapeutics, Aadi Biosciences, Boehringer Ingelheim, Agenus, Regeneron Pharmaceuticals, Advenchen, and Curtis; and speaking fees from Caris, Janssen, Lilly, Target Oncology, Bionest Partners, and Intellisphere LLC. Ethical approval: The research was carried out in accordance with the principles outlined in the Declaration of Helsinki. The Animal Use and Care Committees at Tongji Medical College, Huazhong University of Science and Technology approved approval for the research (IACUC Number: [2023] 3790). Consent for publication: All subjects signed a written informed consent. 13. Multimed Man Cardiothorac Surg. 2024 May 3;2024. doi: 10.1510/mmcts.2024.005. Manubriectomy made easy. Mughal AZ(1), El-Zeki A(1), Oliemy A(1), Habib AM(1). Author information: (1)Cardiothoracic Surgery Department, New Cross Hospital, Royal Wolverhampton NHS Foundation Trust, Wolverhampton, United Kingdom. Bone metastasis is the most common form of distant metastasis encountered within the breast cancer population. Surgical resection of bone metastases is a curative treatment option in patients who present with an isolated solitary lesion and no other associated disease. This decision is typically made following a multidisciplinary discussion. Patients can also be put forward for surgical excision of bone metastases following inadequate response to chemotherapy or radiotherapy.  With tumours located in the manubrium of the sternum, surgery serves not only to resect the bone metastasis but to provide suitable chest wall reconstruction. The goal of this approach is to maintain the structural and bony stability of the chest wall as well as that of associated structures, e.g. rib insertion or articulation of the shoulder girdle. A widely utilized approach involves excising the area of metastasis within the manubrium followed by implanting a bone cement prosthesis. Titanium plates are used to fix the bone prosthesis to the sternal body inferiorly and to the remainder of the manubrium superiorly.  We present a step-by-step video tutorial for performing a lower hemi-manubriectomy in a patient with triple-negative breast cancer. Our goal is to describe the fundamental principles and surgical techniques used to perform this procedure followed by the postoperative outcomes. © The Author 2024. Published by MMCTS on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. DOI: 10.1510/mmcts.2024.005