Sacral fractures.

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Abstract

[Indexed for MEDLINE] 7. Surg Pathol Clin. 2025 Sep;18(3):581-595. doi: 10.1016/j.path.2025.01.003. Epub 2025 Feb 18. Pediatric Bone Tumors. Alston ELJ(1), Ecklund K(2), Al-Ibraheemi A(3). Author information: (1)Department of Pathology, Boston Children's Hospital, Boston, MA, USA. (2)Department of Radiology, Boston Children's Hospital, Boston, MA, USA. (3)Department of Pathology, Boston Children's Hospital, Boston, MA, USA. Electronic address: Alyaa.al-ibraheemi@childrens.harvard.edu. Pediatric bone lesions encompass a diverse spectrum of conditions, including benign neoplasms, cystic lesions, fibro-osseous lesions, and malignant tumors. This review highlights key diagnostic and management principles for commonly encountered non-sarcomatous lesions such as chondroblastoma, giant cell tumor, and aneurysmal bone cyst. Emphasis is placed on integrating clinical presentation, radiographic imaging, histopathological examination, and molecular diagnostics, such as H3.3 mutations and USP6 rearrangements, to refine differential diagnoses. A multidisciplinary approach is essential for optimizing outcomes in pediatric bone tumor care. Copyright © 2025 Elsevier Inc. All rights reserved. DOI: 10.1016/j.path.2025.01.003