Targeting senescent cells to boost bone fracture healing.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Conflict of interest: The authors have declared that no conflict of interest exists. 4. Curr Osteoporos Rep. 2018 Apr;16(2):138-145. doi: 10.1007/s11914-018-0423-2. The Role of the Immune Cells in Fracture Healing. Baht GS(1)(2)(3), Vi L(4), Alman BA(5)(6). Author information: (1)Department of Orthopaedic Surgery, Duke Molecular Physiology Institute, Duke University, DUMC 104775, 300 North Duke Street, Durham, NC, 27701, USA. gurpreet.baht@duke.edu. (2)Duke Molecular Physiology Institute, Durham, NC, USA. gurpreet.baht@duke.edu. (3)Department of Orthopaedic Surgery, Duke University, 200 Trent Drive, Orange Zone 5th floor, Durham, NC, 27710, USA. gurpreet.baht@duke.edu. (4)University of Toronto, Toronto, Canada. (5)Department of Orthopaedic Surgery, Duke Molecular Physiology Institute, Duke University, DUMC 104775, 300 North Duke Street, Durham, NC, 27701, USA. ben.alman@duke.edu. (6)Department of Orthopaedic Surgery, Duke University, 200 Trent Drive, Orange Zone 5th floor, Durham, NC, 27710, USA. ben.alman@duke.edu. PURPOSE OF REVIEW: Bone fracture healing is a complex physiological process relying on numerous cell types and signals. Inflammatory factors secreted by immune cells help to control recruitment, proliferation, differentiation, and activation of hematopoietic and mesenchymal cells. Within this review we will discuss the functional role of immune cells as it pertains to bone fracture healing. In doing so, we will outline the cytokines secreted and their effects within the healing fracture callus. RECENT FINDINGS: Macrophages have been found to play an important role in fracture healing. These immune cells signal to other cells of the fracture callus, modulating bone healing. Cytokines and cellular signals within fracture healing continue to be studied. The findings from this work have helped to reinforce the importance of osteoimmunity in bone fracture healing. Owing to these efforts, immunomodulation is emerging as a potential therapeutic target to improve bone fracture healing. DOI: 10.1007/s11914-018-0423-2 PMCID: PMC5866272