Inflammation-Responsive Functional Core-Shell Micro-Hydrogels Promote Rotator Cuff Tendon-To-Bone Healing by Recruiting MSCs and Immuno-Modulating Macrophages in Rats.

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Abstract

[Indexed for MEDLINE] 11. Phys Med Rehabil Clin N Am. 2023 Feb;34(1):265-274. doi: 10.1016/j.pmr.2022.08.015. Epub 2022 Oct 18. Orthobiologic Techniques for Surgical Augmentation. Lin KM(1), Frey CS(1), Atzmon R(1), Pierre K(1), Vel MS(1), Sherman SL(2). Author information: (1)Sports Medicine Service, Department of Orthopedic Surgery, Stanford University, 430 Broadway, MC 6342, Redwood City, CA 94063, USA. (2)Sports Medicine Service, Department of Orthopedic Surgery, Stanford University, 430 Broadway, MC 6342, Redwood City, CA 94063, USA. Electronic address: shermans@stanford.edu. General awareness and clinical utilization of orthobiologic therapy has increased sharply in the recent years. Orthobiologics can be defined as "biological materials and substrates that promote bone, ligament, muscle, and tendon healing." There are 3 major strategies by which orthobiologics are thought to augment tissue repair or native biologic potential: factor-based, cell-based, and biomechanical augmentation. The purpose of this review is to synthesize the recent literature on orthobiologic techniques for surgical augmentation, with focus on several key areas including meniscus repair, osteochondral grafting, and rotator cuff repair. Published by Elsevier Inc. DOI: 10.1016/j.pmr.2022.08.015