Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition.

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Abstract

Conflict of interest statement: Declarations. Ethics approval and consent to participate: All procedures involving animals were performed in accordance with the guidelines issued by the University of Arkansas for Medical Sciences Institutional Animal Care and Use Committee (IACUC) (protocol #2022200000489). Collection and de-identification of human bone samples for ex vivo studies were coordinated by the UAMS Winthrop P. Rockefeller Cancer Institute TBAPS and approved by the UAMS IRB (protocol # 262940). All study procedures were approved by the University of Arkansas for Medical Sciences (IRB # 260312) and the Mayo Clinic (IRB # 23-012399) institutional review board with a waiver of informed consent owing to the retrospective nature of the data. Trephine iliac crest bone marrow biopsies from patients with MGUS or newly diagnosed MM were retrieved from Danish histopathological biobanks under approval from the Danish National Committee on Biomedical Research Ethics (S-20190110). All human samples were collected and processed in accordance with the Declaration of Helsinki. Competing interests: The authors declare no competing interests. 9. J Clin Med. 2024 Sep 25;13(19):5710. doi: 10.3390/jcm13195710. Imaging of Osteosarcoma: Presenting Findings, Metastatic Patterns, and Features Related to Prognosis. Crombé A(1)(2)(3), Simonetti M(4), Longhi A(5), Hauger O(2), Fadli D(2), Spinnato P(4). Author information: (1)SARCOTARGET Team, Bordeaux Research Institute in Oncology (BRIC) INSERM U1312 & University of Bordeaux, F-33076 Bordeaux, France. (2)Department of Skeletal Radiology, Pellegrin University Hospital, F-33076 Bordeaux, France. (3)Department of Radiology, Institut Bergonié, F-33076 Bordeaux, France. (4)Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy. (5)Osteoncology, Bone and Soft Tissue Sarcomas, and Innovative Therapies, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy. Background: Osteosarcomas are rare malignancies (