Orthonotes
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Evidence Search

Search reputable indexed orthopaedic literature from multiple scholarly sources, classify the evidence, and link papers directly to wiki topics and cases.

Sources: PubMed, Europe PMC, Crossref

Linking results to Wiki: Osteosarcoma — Workup & Management
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Results are classified automatically from source metadata across PubMed, Europe PMC, and Crossref.
PubMed Crossref
PubMed Guideline / Consensus Evidence High

Bone Cancer, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology.

Journal of the National Comprehensive Cancer Network : JNCCN | 2025 | Biermann JS, Hirbe A, Ahlawat S, Bernthal NM

[Indexed for MEDLINE] 2. Hematol Oncol Clin North Am. 2020 Feb;34(1):177-188. doi: 10.1016/j.hoc.2019.09.002. Epub 2019 Oct 28. Bone Sarcomas and Desmoids. Brownstein JM(1), DeLaney TF(2). Author information: (1)Francis H. Burr Proton Beam Therapy Center, Massachusetts General Hospital, 30 Fruit Street, Boston, MA 02114, USA; Department of Radiation Oncology, Comprehensive Canc...

PubMed Systematic Review / Meta-analysis Evidence High

A Systemic Review of Primary Malignant Long Bone Tumors in Children and Adolescents.

Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca | 2024 | Khan M, Patel R, Youssef M, Banerjee R

[Indexed for MEDLINE] 9. Curr Pain Headache Rep. 2025 Dec 15;30(1):8. doi: 10.1007/s11916-025-01450-8. Periosteal Osteosarcoma: Emerging Clinical Concepts, Evolving Treatment Options: A Narrative Review. Bratton MB(1), Pirzadah HA(1), Starns MJ(1), Islam RK(1), Shekoohi S(2), Abd-Elsayed A(3), Kaye AD(4)(5). Author information: (1)School of Medicine, Louisiana State University...

PubMed Narrative Review Evidence Moderate

Periosteal Osteosarcoma: Emerging Clinical Concepts, Evolving Treatment Options: A Narrative Review.

Current pain and headache reports | 2025 | Bratton MB, Pirzadah HA, Starns MJ, Islam RK

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Compliance with Ethical Guidelines: This article is based on previous studies and contains no new studies with human participants or animals performed by any authors. Competing Interests: ADK is the Editor-in-Chief for CPHRs. 10. J Nucl Med. 2023 Sep;64(9):1371-1377. doi: 10.2967/jnumed.122.265278. Epub 2023 Ju...

Crossref Review Article Evidence Moderate

Primary Cardiac Osteosarcoma: Epidemiology, Diagnosis, and Management — A Narrative Review

Orthopedic Reviews | 2025 | Tommy Li, Eric Nguyen, Jamal Hasoon, Ali Khalifa

Purpose Primary cardiac sarcomas are exceedingly rare, with a very low incidence in the general population. A variety of sarcoma subtypes can originate in the heart, including angiosarcoma, rhabdomyosarcoma, leiomyosarcoma, fibrosarcoma, and osteosarcoma. These tumors are typically classified based on histological characteristics, most often determined following surgical excisi...

PubMed Narrative Review Evidence Moderate

Management of Primary Aggressive Tumors of the Knee.

The journal of knee surgery | 2022 | Martin JR, Auran RL, Duran MD, de Comas AM

[Indexed for MEDLINE] Conflict of interest statement: None declared. 6. Oncologist. 2004;9(4):422-41. doi: 10.1634/theoncologist.9-4-422. Biology and therapeutic advances for pediatric osteosarcoma. Marina N(1), Gebhardt M, Teot L, Gorlick R. Author information: (1)Department of Pediatrics, Division of Hematology-Oncology, Stanford University Medical Center, Stanford, Californi...

PubMed Narrative Review Evidence Moderate

Bone Sarcomas and Desmoids.

Hematology/oncology clinics of North America | 2020 | Brownstein JM, DeLaney TF

[Indexed for MEDLINE] 3. Genes Chromosomes Cancer. 2024 Nov;63(11):e70015. doi: 10.1002/gcc.70015. Malignant Bone-Forming Neoplasm With NIPBL::BEND2 Fusion. Dashti NK(1)(2), Matcuk G(3), Agaimy A(4), Saoud C(5), Antonescu CR(5). Author information: (1)Department of Pathology and Laboratory Medicine, Dartmouth Health Medical Center, Lebanon, New Hampshire, USA. (2)Geisel School...

PubMed Cohort / Comparative Study Evidence Moderate

Incidence Trends in the Diagnosis of Giant Cell Tumor of Bone in Sweden Since 1958.

The Journal of bone and joint surgery. American volume | 2015 | Rockberg J, Bach BA, Amelio J, Hernandez RK

[Indexed for MEDLINE] 20. Radiol Clin North Am. 1990 Mar;28(2):461-70. The use of magnetic resonance imaging in the evaluation of bone and soft-tissue tumors. Dalinka MK(1), Zlatkin MB, Chao P, Kricun ME, Kressel HY. Author information: (1)University of Pennsylvania School of Medicine, Philadelphia. We believe that MR imaging should follow plain films in the imaging analysis of...

PubMed Case Report / Series Evidence Low

Malignant Bone-Forming Neoplasm With NIPBL::BEND2 Fusion.

Genes, chromosomes & cancer | 2024 | Dashti NK, Matcuk G, Agaimy A, Saoud C

[Indexed for MEDLINE] 4. Arch Pediatr. 2005 Sep;12(9):1383-91. doi: 10.1016/j.arcped.2005.05.014. [Ewing's tumor]. [Article in French] Taylor M(1), Guillon M, Champion V, Marcu M, Arnoux JB, Hartmann O. Author information: (1)Service d'oncologie pédiatrique, institut Gustave-Roussy, rue Camille-Desmoulins, 94805 Villejuif, France. Ewing's tumor (ET) is a malignant bone tumor oc...

PubMed Case Report / Series Evidence Low

[Extraskeletal Ewing's sarcoma of the parapharyngeal space: a case report].

The Pan African medical journal | 2024 | Aboutajdine F, Filali LM, Houssini AS, Hayat Z

[Indexed for MEDLINE] Conflict of interest statement: Les auteurs ne déclarent aucun conflit d'intérêts. 19. J Bone Joint Surg Am. 2015 Nov 4;97(21):1756-66. doi: 10.2106/JBJS.O.00156. Incidence Trends in the Diagnosis of Giant Cell Tumor of Bone in Sweden Since 1958. Rockberg J(1), Bach BA(2), Amelio J(3), Hernandez RK(4), Sobocki P(1), Engellau J(5), Bauer HC(6), Liede A(7)....

PubMed Case Report / Series Evidence Low

Case Report: Giant cell-rich osteosarcoma of the cervical spine in the pediatric age. A rare entity to consider.

Frontiers in surgery | 2022 | Egea-Gámez RM, Galán-Olleros M, González-Menocal A, González-Díaz R

Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. 18. Pan Afr Med J. 2024 Jul 12;48:103. doi: 10.11604/pamj.2024.48.103.44109. eCollection 2024. [Extraskeletal Ewing's sarcoma of the parapharyngeal space: a case report]. [Art...

PubMed Case Report / Series Evidence Low

Multifocal Osteosarcoma: Multiple Primaries or Metastases? A Report of Rare Case and Review of Literature.

Journal of orthopaedic case reports | 2020 | Agrawal M, Patil A, James T, Kumar N

Conflict of interest statement: Conflict of Interest: Nil 12. Pathol Res Pract. 2022 Mar;231:153777. doi: 10.1016/j.prp.2022.153777. Epub 2022 Jan 21. Diagnosis of giant cell-rich bone tumors on core needle biopsy: A practical approach. Jager L(1), Johnson DN(2), Sukhanova M(2), Streich L(2), Chapa AR(3), Alexiev BA(2). Author information: (1)Department of Pathology, Northweste...

PubMed Original Article Evidence Unclassified

Pediatric Bone Sarcoma Biopsy Tract Excision: Is it Safe to Resect Separately?

Journal of pediatric orthopedics | 2025 | Eckhoff MD, Strub DR, Utset-Ward TJ, Wells ME

[Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest. 14. J Pak Med Assoc. 2022 Apr;72(4):782-783. doi: 10.47391/JPMA.22-33. Diffuse hepatic uptake on bone scan in a terminally ill osteosarcoma patient. Rana MF(1), Hassan A(1). Author information: (1)Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital and Researc...

Crossref Journal Article Evidence Unclassified

Management of Suspected Peripheral Vascular Injuries in Orthopedic Trauma

Orthopaedic Surgery | 2024 | Bo Li, Xuan Tian, Han Fei, Guoshen Li

ObjectiveIn orthopedic trauma, identification of extremity trauma combined with vascular injury is challenging. Missed diagnosis may result in amputation or even death. The purpose of this study was to investigate whether physical examination combined with handheld vascular ultrasound Doppler examination could be an effective method of screening for peripheral vascular injury a...

PubMed Original Article Evidence Unclassified

[(18)F]FDG PET/CT in the Initial Staging and Restaging of Soft-Tissue or Bone Sarcoma in Patients with Negative or Equivocal Findings for Metastases or Limited Recurrence on Conventional Work-up: Results of a Prospective Multicenter Registry.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine | 2023 | Metser U, Kulanthaivelu R, Salawu A, Razak A

[Indexed for MEDLINE] 11. J Orthop Case Rep. 2020 Nov;10(8):97-100. doi: 10.13107/jocr.2020.v10.i08.1878. Multifocal Osteosarcoma: Multiple Primaries or Metastases? A Report of Rare Case and Review of Literature. Agrawal M(1), Patil A(1), James T(1), Kumar N(2), Premalata CS(1). Author information: (1)Department of Pathology, Kidwai Memorial Institute of Oncology, Dr. M. H. Mar...

PubMed Original Article Evidence Unclassified

Diagnosis of giant cell-rich bone tumors on core needle biopsy: A practical approach.

Pathology, research and practice | 2022 | Jager L, Johnson DN, Sukhanova M, Streich L

[Indexed for MEDLINE] 13. J Pediatr Orthop. 2025 May-Jun 01;45(5):e486-e491. doi: 10.1097/BPO.0000000000002889. Epub 2025 Jan 14. Pediatric Bone Sarcoma Biopsy Tract Excision: Is it Safe to Resect Separately? Eckhoff MD(1)(2), Strub DR(1), Utset-Ward TJ(1), Wells ME(3), Scharschmidt TJ(1). Author information: (1)Department of Orthopaedic Surgery, Nationwide Children's Hospital....

PubMed Original Article Evidence Unclassified

Diffuse hepatic uptake on bone scan in a terminally ill osteosarcoma patient.

JPMA. The Journal of the Pakistan Medical Association | 2022 | Rana MF, Hassan A

[Indexed for MEDLINE] 15. Int Semin Surg Oncol. 2006 Nov 3;3:38. doi: 10.1186/1477-7800-3-38. Multidisciplinary approach to diagnosis and management of osteosarcoma - a review of the St Vincent's Hospital experience. Tan JZ(1), Schlicht SM, Powell GJ, Thomas D, Slavin JL, Smith PJ, Choong PF. Author information: (1)Department of Medical Imaging, St Vincent's Hospital, Melbourne...

PubMed Narrative Review Evidence Moderate

Multidisciplinary approach to diagnosis and management of osteosarcoma - a review of the St Vincent's Hospital experience.

International seminars in surgical oncology : ISSO | 2006 | Tan JZ, Schlicht SM, Powell GJ, Thomas D

16. J Orthop Case Rep. 2016 Jan-Mar;6(1):72-5. doi: 10.13107/jocr.2250-0685.383. Management of Pelvic Chondroblastic Osteosarcoma after Urgent Spinal Decompression - A Report of 2 Cases. Scudday TS(1), Danisa OA(1), Zuckerman LM(1). Author information: (1)Department of Orthopaedic Surgery, Loma Linda University Medical Center. Loma Linda, CA, USA. INTRODUCTION: Pelvic sarcoma p...

PubMed Case Report / Series Evidence Low

Management of Pelvic Chondroblastic Osteosarcoma after Urgent Spinal Decompression - A Report of 2 Cases.

Journal of orthopaedic case reports | 2016 | Scudday TS, Danisa OA, Zuckerman LM

Conflict of interest statement: Conflict of Interest: Nil 17. Front Surg. 2022 Oct 14;9:1001149. doi: 10.3389/fsurg.2022.1001149. eCollection 2022. Case Report: Giant cell-rich osteosarcoma of the cervical spine in the pediatric age. A rare entity to consider. Egea-Gámez RM(1), Galán-Olleros M(1), González-Menocal A(2), González-Díaz R(1). Author information: (1)Spine Unit. Ort...

PubMed Narrative Review Evidence Moderate

[Ewing's tumor].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie | 2005 | Taylor M, Guillon M, Champion V, Marcu M

[Indexed for MEDLINE] 5. J Knee Surg. 2022 May;35(6):585-596. doi: 10.1055/s-0042-1743221. Epub 2022 Feb 18. Management of Primary Aggressive Tumors of the Knee. Martin JR(1), Auran RL(1), Duran MD(2), de Comas AM(1)(2), Jacofsky DJ(2). Author information: (1)Department of Orthopaedic Surgery, University of Arizona College of Medicine, Phoenix, Arizona. (2)The Center for Orthop...

PubMed Narrative Review Evidence Moderate

Biology and therapeutic advances for pediatric osteosarcoma.

The oncologist | 2004 | Marina N, Gebhardt M, Teot L, Gorlick R

[Indexed for MEDLINE] 7. JAAPA. 2019 Dec;32(12):14-20. doi: 10.1097/01.JAA.0000604852.26078.91. Evaluating low back pain in adolescents. Garvick SJ(1), Creecy C, Miller M, Schafer L, Spooner A, Tazewell AW, Gregory T. Author information: (1)Sarah J. Garvick is associate program director of the PA program at the Boone, N.C., campus of Wake Forest School of Medicine. Candice Cree...

PubMed Original Article Evidence Unclassified

Evaluating low back pain in adolescents.

JAAPA : official journal of the American Academy of Physician Assistants | 2019 | Garvick SJ, Creecy C, Miller M, Schafer L

[Indexed for MEDLINE] 8. Acta Chir Orthop Traumatol Cech. 2024;91(2):77-87. doi: 10.55095/ACHOT2024/010. A Systemic Review of Primary Malignant Long Bone Tumors in Children and Adolescents. [Article in English] Khan M(1), Patel R(1)(2)(3), Youssef M(3), Banerjee R(1), Pardiwala A(4), Belen C(5). Author information: (1)Department of Trauma and Orthopaedics, Robert Jones and Agne...