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Evidence Search

Search reputable indexed orthopaedic literature from multiple scholarly sources, classify the evidence, and link papers directly to wiki topics and cases.

Sources: PubMed, Europe PMC, Crossref

Linking results to Wiki: Approach to Lytic Bone Lesions
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Results are classified automatically from source metadata across PubMed, Europe PMC, and Crossref.
PubMed Crossref
PubMed Narrative Review Evidence Moderate

Imaging of Osteosarcoma: Presenting Findings, Metastatic Patterns, and Features Related to Prognosis.

Journal of clinical medicine | 2024 | Crombé A, Simonetti M, Longhi A, Hauger O

Conflict of interest statement: The authors declare no conflicts of interest. 11. Am Fam Physician. 2002 Mar 15;65(6):1123-32. Osteosarcoma: a multidisciplinary approach to diagnosis and treatment. Wittig JC(1), Bickels J, Priebat D, Jelinek J, Kellar-Graney K, Shmookler B, Malawer MM. Author information: (1)Washington Cancer Institute, Washington Hospital Center, DC, USA. witt...

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PubMed Narrative Review Evidence Moderate

Fungal Musculoskeletal Infections: Comprehensive Approach to Proper Diagnosis.

Radiographics : a review publication of the Radiological Society of North America, Inc | 2024 | Akuri MC, Bencardino JT, Peixoto JB, Sato VN

[Indexed for MEDLINE] 13. Radiographics. 2012 Nov-Dec;32(7):1909-25. doi: 10.1148/rg.327125003. Radiopaque jaw lesions: an approach to the differential diagnosis. Curé JK(1), Vattoth S, Shah R. Author information: (1)Department of Radiology, Neuroradiology Section, University of Alabama at Birmingham, Birmingham, Ala., USA. Radiopaque jaw lesions are frequently encountered at r...

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PubMed Narrative Review Evidence Moderate

Good Cop, Bad Cop: Profiling the Immune Landscape in Multiple Myeloma.

Biomolecules | 2023 | Sharma NS, Choudhary B

[Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflict of interest. 16. Am Fam Physician. 2008 Oct 1;78(7):853-9. Multiple myeloma: diagnosis and treatment. Nau KC(1), Lewis WD. Author information: (1)West Virginia University, Department of Family Medicine, Eastern Division, Harpers Ferry, West Virginia 26425, USA. nauk@rcbhsc.wvu.edu Multiple mye...

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PubMed Narrative Review Evidence Moderate

Bone Metastases: From Mechanisms to Treatment.

Seminars in oncology nursing | 2022 | Riffel RM, Göbel A, Rachner TD

[Indexed for MEDLINE] Conflict of interest statement: Declaration of Competing Interest The authors have received grants or honorarium for advisory boards or lectures to the individual or the institution by Amgen (TDR), Biomedica (AG), RMR has no conflicts of interest. 4. Curr Opin Hematol. 1998 Jan;5(1):54-8. doi: 10.1097/00062752-199801000-00010. Langerhans cell histiocytosis...

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PubMed Narrative Review Evidence Moderate

Bone lesions in hairy cell leukemia: Diagnosis and treatment.

European journal of haematology | 2020 | Robak P, Jesionek-Kupnicka D, Kupnicki P, Polliack A

[Indexed for MEDLINE] 7. Bone Res. 2025 Jan 16;13(1):9. doi: 10.1038/s41413-024-00384-y. Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis. Jia Y(1)(2), Li R(3), Li Y(1)(2), Kachler K(1)(2), Meng X(1)(2), Gießl A(4), Qin Y(1)(2), Zhang F(1)(2), Liu N(1)(2), Andreev D(1)(2)(5), Schett G(1)(2), Bozec A(6)(7). Author information: (1)Department of Inte...

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PubMed Narrative Review Evidence Moderate

Integrating the immune microenvironment of prostate cancer induced bone disease.

Molecular carcinogenesis | 2020 | Ihle CL, Owens P

[Indexed for MEDLINE] 20. Oncologist. 2014 May;19(5):550-61. doi: 10.1634/theoncologist.2013-0432. Epub 2014 Apr 9. The clinical approach toward giant cell tumor of bone. van der Heijden L(1), Dijkstra PD, van de Sande MA, Kroep JR, Nout RA, van Rijswijk CS, Bovée JV, Hogendoorn PC, Gelderblom H. Author information: (1)Departments of Orthopedic Surgery, Clinical Oncology, Radio...

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PubMed Narrative Review Evidence Moderate

Interventional Techniques for the Ablation and Augmentation of Extraspinal Lytic Bone Metastases.

Seminars in interventional radiology | 2019 | Ahmed O, Feinberg N, Lea WB

Conflict of interest statement: Conflict of Interest None. 18. Nat Commun. 2025 Jan 31;16(1):1206. doi: 10.1038/s41467-025-56506-5. EZH2 serves as a viable therapeutic target for myeloma-induced osteolytic bone destruction. Liu R(#)(1), Li Z(#)(2), Chen R(1), Fang Z(3)(4), Liu Z(5), Liu H(6)(7)(8)(9). Author information: (1)Cancer Research Center, School of Medicine, Xiamen Uni...

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PubMed Narrative Review Evidence Moderate

Multiple Myeloma and Bone: The Fatal Interaction.

Cold Spring Harbor perspectives in medicine | 2018 | Marino S, Roodman GD

[Indexed for MEDLINE] 10. J Clin Med. 2024 Sep 25;13(19):5710. doi: 10.3390/jcm13195710. Imaging of Osteosarcoma: Presenting Findings, Metastatic Patterns, and Features Related to Prognosis. Crombé A(1)(2)(3), Simonetti M(4), Longhi A(5), Hauger O(2), Fadli D(2), Spinnato P(4). Author information: (1)SARCOTARGET Team, Bordeaux Research Institute in Oncology (BRIC) INSERM U1312...

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PubMed Narrative Review Evidence Moderate

Myeloma today: Disease definitions and treatment advances.

American journal of hematology | 2016 | Rajkumar SV

[Indexed for MEDLINE] Conflict of interest statement: Disclosure of Conflicts of Interest SVR declares no conflict of interest. 15. Biomolecules. 2023 Nov 7;13(11):1629. doi: 10.3390/biom13111629. Good Cop, Bad Cop: Profiling the Immune Landscape in Multiple Myeloma. Sharma NS(1)(2), Choudhary B(1). Author information: (1)Institute of Bioinformatics and Applied Biotechnology (I...

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PubMed Narrative Review Evidence Moderate

Radiopaque jaw lesions: an approach to the differential diagnosis.

Radiographics : a review publication of the Radiological Society of North America, Inc | 2012 | Curé JK, Vattoth S, Shah R

[Indexed for MEDLINE] 14. Am J Hematol. 2016 Jan;91(1):90-100. doi: 10.1002/ajh.24236. Myeloma today: Disease definitions and treatment advances. Rajkumar SV(1). Author information: (1)Division of Hematology, Mayo Clinic, Rochester, Minnesota. Erratum in Am J Hematol. 2016 Sep;91(9):965. doi: 10.1002/ajh.24392. There have been major advances in the diagnosis, staging, risk-stra...

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PubMed Narrative Review Evidence Moderate

Plasma cell leukemia.

Blood reviews | 2011 | Albarracin F, Fonseca R

[Indexed for MEDLINE] 3. Semin Oncol Nurs. 2022 Apr;38(2):151277. doi: 10.1016/j.soncn.2022.151277. Epub 2022 Apr 23. Bone Metastases: From Mechanisms to Treatment. Riffel RM(1), Göbel A(1), Rachner TD(2). Author information: (1)Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technische Universität Dresden, Dresden, Germany; Center for Health...

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PubMed Original Article Evidence Unclassified

Melanoma bone metastasis-induced osteocyte ferroptosis via the HIF1α-HMOX1 axis.

Bone research | 2025 | Jia Y, Li R, Li Y, Kachler K

[Indexed for MEDLINE] Conflict of interest statement: Competing interests: The authors declare no competing interests. 8. Exp Hematol Oncol. 2025 Aug 22;14(1):108. doi: 10.1186/s40164-025-00699-4. Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition. Sabol HM(1), Anloague A(1), Kaur J(1)(2), Bustamante-Gomez C(3), Khan S(1),...

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PubMed Original Article Evidence Unclassified

Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition.

Experimental hematology & oncology | 2025 | Sabol HM, Anloague A, Kaur J, Bustamante-Gomez C

Conflict of interest statement: Declarations. Ethics approval and consent to participate: All procedures involving animals were performed in accordance with the guidelines issued by the University of Arkansas for Medical Sciences Institutional Animal Care and Use Committee (IACUC) (protocol #2022200000489). Collection and de-identification of human bone samples for ex vivo stud...

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PubMed Original Article Evidence Unclassified

EZH2 serves as a viable therapeutic target for myeloma-induced osteolytic bone destruction.

Nature communications | 2025 | Liu R, Li Z, Chen R, Fang Z

[Indexed for MEDLINE] Conflict of interest statement: Competing interests: The authors declare no competing interests. 19. Mol Carcinog. 2020 Jul;59(7):822-829. doi: 10.1002/mc.23192. Epub 2020 Mar 31. Integrating the immune microenvironment of prostate cancer induced bone disease. Ihle CL(1), Owens P(1)(2). Author information: (1)Department of Pathology, University of Colorado...

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PubMed Narrative Review Evidence Moderate

Multiple myeloma: diagnosis and treatment.

American family physician | 2008 | Nau KC, Lewis WD

[Indexed for MEDLINE] 17. Semin Intervent Radiol. 2019 Aug;36(3):221-228. doi: 10.1055/s-0039-1693117. Epub 2019 Aug 19. Interventional Techniques for the Ablation and Augmentation of Extraspinal Lytic Bone Metastases. Ahmed O(1), Feinberg N(1), Lea WB(2). Author information: (1)Section of Interventional Radiology, Department of Radiology, University of Chicago Medicine, Chicag...

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PubMed Narrative Review Evidence Moderate

Osteosarcoma: a multidisciplinary approach to diagnosis and treatment.

American family physician | 2002 | Wittig JC, Bickels J, Priebat D, Jelinek J

[Indexed for MEDLINE] 12. Radiographics. 2024 Jul;44(7):e230176. doi: 10.1148/rg.230176. Fungal Musculoskeletal Infections: Comprehensive Approach to Proper Diagnosis. Akuri MC(1), Bencardino JT(1), Peixoto JB(1), Sato VN(1), Miyahara LK(1), Kase DT(1), Dell'Aquila AM(1), do Amaral E Castro A(1), Fernandes ARC(1), Aihara AY(1). Author information: (1)From the Department of Diag...

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PubMed Narrative Review Evidence Moderate

Langerhans cell histiocytosis.

Current opinion in hematology | 1998 | Ladisch S

[Indexed for MEDLINE] 5. Semin Hematol. 1987 Jul;24(3):202-8. Plasma cell leukemia. Kosmo MA(1), Gale RP. Author information: (1)Division of Hematology/Oncology, Naval Hospital, San Diego, CA 92134. Erratum in Semin Hematol 1987 Oct;24(4):xvii. In summary, plasma cell leukemia is a rare disorder that can develop spontaneously or evolve in patients with multiple myeloma. The dia...

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PubMed Narrative Review Evidence Moderate

Histiocytoses.

European journal of pediatrics | 1995 | Stéphan JL

[Indexed for MEDLINE] 2. Blood Rev. 2011 May;25(3):107-12. doi: 10.1016/j.blre.2011.01.005. Epub 2011 Feb 3. Plasma cell leukemia. Albarracin F(1), Fonseca R. Author information: (1)Hematology Division, Hospital Central, Mendoza, Argentina. Plasma cell leukemia (PCL) is a rare, yet aggressive plasma cell (PC) neoplasm, variant of multiple myeloma (MM), characterized by high lev...

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PubMed Narrative Review Evidence Moderate

Plasma cell leukemia.

Seminars in hematology | 1987 | Kosmo MA, Gale RP

[Indexed for MEDLINE] 6. Eur J Haematol. 2020 Dec;105(6):682-691. doi: 10.1111/ejh.13505. Epub 2020 Aug 19. Bone lesions in hairy cell leukemia: Diagnosis and treatment. Robak P(1), Jesionek-Kupnicka D(2), Kupnicki P(3)(4), Polliack A(5), Robak T(6). Author information: (1)Department of Experimental Hematology, Medical University of Lodz and Copernicus Memorial Hospital, Lodz,...

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