Evidence Search

Heterotopic Ossification After Shoulder Arthroplasty: A Systematic Review.

The Journal of the American Academy of Orthopaedic Surgeons | 2025 | Nadeem FA, Hayes CV, Jones JR, Hargreaves MD

[Indexed for MEDLINE] 11. ANZ J Surg. 2002 Nov;72(11):808-21. doi: 10.1046/j.1445-2197.2002.02549.x. Incidence of heterotopic bone formation after major hip surgery. Neal B(1), Gray H, MacMahon S, Dunn L. Author information: (1)Institute for International Health, University of Sydney, New South Wales, Australia. bneal@med.usyd.edu.au BACKGROUND: Heterotopic bone formation is a...

Periprosthetic joint infection and heterotopic ossification after total hip arthroplasty: systematic review and meta-analysis.

BMC musculoskeletal disorders | 2025 | Pulik Ł, Łęgosz P, Brzóska E, Mierzejewski B

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Clinical trial number: Not applicable. 20. Bone Joint J. 2016 Sep;98-B(9):1215-21. doi: 10.1302/0301-620X.98B9.37761. Heterotopic ossification aft...

Total Hip Arthroplasty Complications in Sickle Cell Disease: Systematic Review and Meta-Analysis.

Journal of clinical medicine | 2024 | Alfaya FF, Ghazy RM, Hammouda EA, Mahfouz AA

Conflict of interest statement: The authors declare no conflicts of interest. 19. BMC Musculoskelet Disord. 2025 Aug 8;26(1):768. doi: 10.1186/s12891-025-09045-5. Periprosthetic joint infection and heterotopic ossification after total hip arthroplasty: systematic review and meta-analysis. Pulik Ł(#)(1), Łęgosz P(#)(2), Brzóska E(3), Mierzejewski B(3), Grabowska I(3), Ciemerych...

Diclofenac for prophylaxis of heterotopic ossification after hip arthroplasty: a systematic review.

Hip international : the journal of clinical and experimental research on hip pathology and therapy | 2022 | Haffer H, Müller M, Ascherl R, Perka C

[Indexed for MEDLINE] 9. Semin Musculoskelet Radiol. 2017 Nov;21(5):616-629. doi: 10.1055/s-0037-1606137. Epub 2017 Oct 12. Advanced MR Imaging after Total Hip Arthroplasty: The Clinical Impact. Khodarahmi I(1)(2), Fritz J(1). Author information: (1)Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryla...

Heterotopic Ossification after Trauma.

The Orthopedic clinics of North America | 2023 | Lawand J, Loeffelholz Z, Khurshid B, Barcak E

[Indexed for MEDLINE] 3. Perm J. 2020;24:19.211. doi: 10.7812/TPP/19.211. Epub 2020 Feb 7. Awareness of Heterotopic Ossification in Total Joint Arthroplasty: A Primer. Lespasio MJ(1), Guarino AJ. Author information: (1)Department of Orthopedic Surgery, Boston Medical Center, MA. Heterotopic ossification (HO) is the presence of normal bone in soft tissue where bone should not ex...

Awareness of Heterotopic Ossification in Total Joint Arthroplasty: A Primer.

The Permanente journal | 2020 | Lespasio MJ, Guarino AJ

[Indexed for MEDLINE] Conflict of interest statement: Disclosure Statement The author(s) have no conflicts of interest to disclose. 4. Semin Nucl Med. 2018 Sep;48(5):425-438. doi: 10.1053/j.semnuclmed.2018.05.002. Epub 2018 Jun 19. SPECT/CT in Postoperative Painful Hip Arthroplasty. Van den Wyngaert T(1), Paycha F(2), Strobel K(3), Kampen WU(4), Kuwert T(5), van der Bruggen W(6...

SPECT/CT in Postoperative Painful Hip Arthroplasty.

Seminars in nuclear medicine | 2018 | Van den Wyngaert T, Paycha F, Strobel K, Kampen WU

[Indexed for MEDLINE] 5. Curr Opin Rheumatol. 1999 Mar;11(2):127-31. doi: 10.1097/00002281-199903000-00008. Heterotopic bone formation after joint replacement. Nilsson OS(1), Persson PE. Author information: (1)Department of Orthopaedics, Uppsala University Hospital, Sweden. Bone formation outside the skeleton, heterotopic ossification (HO), is a common finding on radiographs fr...

Advanced MR Imaging after Total Hip Arthroplasty: The Clinical Impact.

Seminars in musculoskeletal radiology | 2017 | Khodarahmi I, Fritz J

[Indexed for MEDLINE] Conflict of interest statement: Disclosure The authors report no conflicts of interest in this work. 10. J Am Acad Orthop Surg. 2025 Jun 1;33(11):585-593. doi: 10.5435/JAAOS-D-24-00063. Epub 2024 Dec 10. Heterotopic Ossification After Shoulder Arthroplasty: A Systematic Review. Nadeem FA(1), Hayes CV, Jones JR, Hargreaves MD, Brabston EW, Casp AJ, Momaya A...

Heterotopic ossification after total hip arthroplasty.

American journal of orthopedics (Belle Mead, N.J.) | 2011 | Cohn RM, Schwarzkopf R, Jaffe F

[Indexed for MEDLINE] 7. Eur J Orthop Surg Traumatol. 2023 May;33(4):1037-1041. doi: 10.1007/s00590-022-03244-9. Epub 2022 Mar 19. Heterotopic ossification in primary total hip arthroplasty: risk factor analysis. Aprato A(1), Cambursano S(2), Artiaco S(2), Bevilacqua S(2), Catalani P(2), Massè A(2). Author information: (1)University of Turin, Viale 25 aprile 137 int 6, 10133, T...

CASC20 IS A SUSCEPTIBILITY GENE FOR HETEROTOPIC OSSIFICATION AFTER HIP ARTHROPLASTY

Orthopaedic Proceedings | 2026 | J Mark Wilkinson

Purpose The term heterotopic ossification (HO) describes bone formation that occurs within tissues that do not normally ossify, resulting in pain and disability. However, why some patients suffer HO and others do not is unstudied. Methods Here, we use genome-wide association analysis in a population of ~1,000 patients after hip replacement (~40% with some degree of HO formation...

Heterotopic hip ossification resection: monocentric experiences of associated factors, outcomes, and complications.

International orthopaedics | 2024 | Zampogna B, Laudisio A, Papalia GF, Vorini F

[Indexed for MEDLINE] 13. J Orthop Surg Res. 2022 Mar 5;17(1):147. doi: 10.1186/s13018-022-02959-z. Heterotopic ossification after total hip arthroplasty: When is development completed? Willburger RE(1), Brinkhoff F(1), Nottenkämper J(1), Krapp J(1), Oberberg S(2). Author information: (1)Department of Orthopaedic Surgery, Martin-Luther-Krankenhaus, Voedestrasse 79, 44866, Bochu...

Heterotopic ossification in primary total hip arthroplasty: risk factor analysis.

European journal of orthopaedic surgery & traumatology : orthopedie traumatologie | 2023 | Aprato A, Cambursano S, Artiaco S, Bevilacqua S

[Indexed for MEDLINE] Conflict of interest statement: The authors declare that there is no conflict of interest. 8. Hip Int. 2022 Mar;32(2):144-151. doi: 10.1177/1120700020978194. Epub 2020 Dec 3. Diclofenac for prophylaxis of heterotopic ossification after hip arthroplasty: a systematic review. Haffer H(1), Müller M(1), Ascherl R(1), Perka C(1), Winkler T(1)(2)(3). Author info...

Heterotopic ossification after total hip arthroplasty: When is development completed?

Journal of orthopaedic surgery and research | 2022 | Willburger RE, Brinkhoff F, Nottenkämper J, Krapp J

[Indexed for MEDLINE] Conflict of interest statement: All authors declare that they have no competing interests. 14. J Bone Joint Surg Am. 2021 Jul 21;103(14):1328-1334. doi: 10.2106/JBJS.20.01586. Heterotopic Ossification Following Arthroplasty for Femoral Neck Fracture. Comeau-Gauthier M(1), Zura RD(2), Bzovsky S(1), Schemitsch EH(3), Axelrod D(1), Avram V(1), Manjoo A(1), Po...

Heterotopic ossification after total hip arthroplasty: radiological comparison between a direct anterior approach without an orthopaedic table and a posterior approach

HIP International | 2022 | Naïm Zran, Etienne Joseph, Gabriel Callamand, Xavier Ohl

Introduction: Heterotopic ossification (HO) occurs in almost ⅓ of total hip arthroplasties (THAs). A direct anterior approach (DAA) with an orthopaedic table is less likely to cause HO than a posterior approach. Without an orthopaedic table, the exposure of the femur requires additional soft tissue release. Soft tissue trauma leads to the production of HO inductors. Our study e...

Heterotopic Ossification Following Arthroplasty for Femoral Neck Fracture.

The Journal of bone and joint surgery. American volume | 2021 | Comeau-Gauthier M, Zura RD, Bzovsky S, Schemitsch EH

[Indexed for MEDLINE] Conflict of interest statement: Disclosure: The Hip Fracture Evaluation with Alternatives of Total Hip Arthroplasty versus Hemiarthroplasty (HEALTH) trial was supported by research grants from the Canadian Institutes of Health Research (CIHR) (MCT-90168), National Institutes of Health (NIH) (1UM1AR063386-01), ZorgOnderzoek Nederland-medische wetensehappen...

Prevention of heterotopic ossification after total hip replacement with NSAIDs.

Pharmacy world & science : PWS | 2003 | Fijn R, Koorevaar RT, Brouwers JR

[Indexed for MEDLINE] 16. Bone Joint J. 2017 Oct;99-B(10):1399-1408. doi: 10.1302/0301-620X.99B10.BJJ-2016-1261.R2. Cemented total hip arthroplasty following acetabular fracture. Scott CEH(1), MacDonald D(1), Moran M(1), White TO(1), Patton JT(1), Keating JF(1). Author information: (1)Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh EH16 4SA...

Heterotopic ossification.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine | 2002 | Shehab D, Elgazzar AH, Collier BD

[Indexed for MEDLINE] 2. Orthop Clin North Am. 2023 Jan;54(1):37-46. doi: 10.1016/j.ocl.2022.08.007. Heterotopic Ossification after Trauma. Lawand J(1), Loeffelholz Z(2), Khurshid B(3), Barcak E(2). Author information: (1)Department of Orthopaedic Surgery, John Peter Smith Health Network, Fort Worth, Texas, USA. Electronic address: jadjlawand@gmail.com. (2)Department of Orthopa...

Incidence of heterotopic bone formation after major hip surgery.

ANZ journal of surgery | 2002 | Neal B, Gray H, MacMahon S, Dunn L

[Indexed for MEDLINE] 12. Int Orthop. 2024 Mar;48(3):699-704. doi: 10.1007/s00264-023-05993-6. Epub 2023 Sep 30. Heterotopic hip ossification resection: monocentric experiences of associated factors, outcomes, and complications. Zampogna B(1)(2), Laudisio A(3)(4)(5), Papalia GF(1)(2), Vorini F(1)(2), Zampoli A(1)(2), Righini R(1)(2), Fiore M(6)(7), Vadalà G(1)(2), Angeletti S(8...

Cemented total hip arthroplasty following acetabular fracture.

The bone & joint journal | 2017 | Scott CEH, MacDonald D, Moran M, White TO

[Indexed for MEDLINE] 17. J Am Acad Orthop Surg. 2002 Nov-Dec;10(6):409-16. doi: 10.5435/00124635-200211000-00005. Heterotopic ossification after hip and knee arthroplasty: risk factors, prevention, and treatment. Iorio R(1), Healy WL. Author information: (1)Department of Orthopaedic Surgery, Lahey Clinic Medical Center, Burlington, MA, USA. Symptomatic heterotopic ossification...

Heterotopic ossification after hip and knee arthroplasty: risk factors, prevention, and treatment.

The Journal of the American Academy of Orthopaedic Surgeons | 2002 | Iorio R, Healy WL

[Indexed for MEDLINE] 18. J Clin Med. 2024 Jul 15;13(14):4129. doi: 10.3390/jcm13144129. Total Hip Arthroplasty Complications in Sickle Cell Disease: Systematic Review and Meta-Analysis. Alfaya FF(1), Ghazy RM(2), Hammouda EA(3)(4), Mahfouz AA(2)(5), Faya HK(6), Asiri MAM(6), Alalmaie OHM(6), Alshahrani NY(6), Alqahtani AZA(6), Alshahrani AY(6), Abdelmoneim SA(3)(7). Author inf...

Heterotopic Ossification

Complications after Primary Total Hip Arthroplasty | 2017 | Michael J. Taunton

Heterotopic ossification after reverse total shoulder arthroplasty.

The bone & joint journal | 2016 | Verhofste B, Decock T, Van Tongel A, De Wilde L

[Indexed for MEDLINE]

Heterotopic bone formation after joint replacement.

Current opinion in rheumatology | 1999 | Nilsson OS, Persson PE

[Indexed for MEDLINE] 6. Am J Orthop (Belle Mead NJ). 2011 Nov;40(11):E232-5. Heterotopic ossification after total hip arthroplasty. Cohn RM(1), Schwarzkopf R, Jaffe F. Author information: (1)Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, New York, 10003, USA. randy.cohn@nyumc.org Heterotopic ossification (HO), the development of bone outsid...

Incidence of Heterotopic Ossification in Patients Receiving Radiation Therapy following Total Hip Arthroplasty

Advances in Orthopedic Surgery | 2014 | Panagiotis Koulouvaris, David Sherr, Thomas Sculco

Heterotopic ossification (HO) is a frequent complication of hip surgery. In this study the incidence of HO is analyzed in high risk patients who received radiation therapy (RT) after total hip replacement (THA) with regular and miniposterolateral hip approach. Two hundred and thirty five high risk patients received a single dose of 700 rad after THA. The incidence of HO was 15....

Avoiding and Treating Heterotopic Ossification After Total Hip Arthroplasty

Seminars in Arthroplasty | 2012 | Torrance A. Walker, William M. Mihalko

Heterotopic ossification of the hip after stroke

Current Orthopaedic Practice | 2011 | Rebecca Ann Halas, Saravanavail Karuppiah

Severe heterotopic ossification after total hip arthroplasty in Schnitzler syndrome

HIP International | 2010 | Emilio Romanini, Massimiliano Magaletti, Lucrezia D'Aviera, Stefano Antonelli

Schnitzler syndrome is a rare disorder characterized by monoclonal IgM gammopathy, urticaria, recurrent fever, evidence of inflammation, bone pain, and arthralgia. We present the case of a patient affected by Schnitzler syndrome who developed Della Valle type C heterotopic ossification after total hip arthroplasty. A relationship between the underlying syndrome and the consider...

Complications after Total Hip Arthroplasty: Heterotopic Ossification

Seminars in Arthroplasty | 2005 | Stephen R. Kantor, Justin Cummins, Michael Tanzer

Trochanteric Heterotopic Ossification After Total Hip Arthroplasty Performed Using a Direct Lateral Approach

The Journal of Arthroplasty | 2005 | Steven F. Harwin

Biochemical markers of bone turnover and development of heterotopic ossification after total hip arthroplasty

Journal of Orthopaedic Research | 2003 | J. Mark Wilkinson, Ian Stockley, Andrew J. Hamer, N. Ann Barrington

AbstractWe studied biochemical markers of bone turnover markers in 20 men and women over 26 weeks after total hip arthroplasty (THA) in order to characterize the changes in bone metabolism associated with developing heterotopic ossification (HO). Transient increases in biochemical markers of both osteoclast and osteoblast activity occurred after surgery. Subjects developing HO...

Risk factors for heterotopic ossification in total hip arthroplasty

Archives of Orthopaedic and Trauma Surgery | 2001 | S. Eggli, A. Woo

Heterotopic Ossification

Revision Total Hip Arthroplasty | 1999 | Douglas E. Padgett

Heterotopic Bone Formation after Total Hip Arthroplasty

Orthopedic Clinics of North America | 1992 | Bert J. Thomas