Long-Term Changes in Parameters of Bone Quality in Kidney Transplant Recipients Treated with Denosumab.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Disclosure: DG has received advisory board honoraria, consultancy fees, and/or speaker fees from Amgen, Celgene, Eli-Lilly, MSD-Italia, Organon, and UCB. MR has received advisory board honoraria, consultancy fees and/or speaker fees from Abbvie, Eli-Lilly, Italfarmaco, Neopharmed-Gentili, Theramex, and UCB. GG has received speaker and advisory board honoraria from Vifor Pharma. PMF received consultant fees and grant/other support from Allena Pharmaceuticals, Alnylam, Amgen, AstraZeneca, Bayer, BioHealth Italia, Gilead, Novo Nordisk, Otsuka Pharmaceuticals, Rocchetta, and Vifor Fresenius and royalties as an author for UpToDate. All other authors declare no conflict of interest. Human and Animal Rights and Informed Consent: The study was conducted within the protocol 1483CESC approved by our local Ethics Committee, in accordance with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The clinical and research activities being reported are consistent with the Principles of the Declaration of Istanbul as outlined in the “Declaration of Istanbul on Organ Trafficking and Transplant Tourism.” Written informed consent was obtained from all participants included. 18. Int Orthop. 2024 Jan;48(1):79-93. doi: 10.1007/s00264-023-05943-2. Epub 2023 Sep 5. Total hip arthroplasty in active and advanced tubercular arthritis: a systematic review of the current evidence. Viswanathan VK(1), Patralekh MK(2), Kalanjiyam GP(3), Iyengar KP(4), Jain VK(5). Author information: (1)Department of Orthopedics, University of Calgary, Calgary, Alberta, Canada. (2)Central Institute of Orthopaedics, Safdarjung Hospital New Delhi, New Delhi, India. (3)Ganga Medical Center and Hospital, Coimbatore, Tamil Nadu, India. (4)Trauma and Orthopaedic Surgeon, Southport and Ormskirk NHS Trust, Southport, PR8 6PN, UK. (5)Department of Orthopaedics, AtalBihari Vajpayee Institute of Medical Sciences, Dr. Ram ManoharLohia Hospital, New Delhi, 110001, India. drvijayortho@gmail.com. STUDY DESIGN: Systematic review. INTRODUCTION: Total hip arthroplasty (THA) is a well-acknowledged surgical intervention to restore a painless and mobile joint in patients with osteoarticular tubercular arthritis of the hip joint. However, there is still substantial uncertainty about the ideal management, clinical and functional outcomes following THA undertaken in patients with acute Mycobacterium tuberculosis (TB) hip infections. AIM OF THE STUDY: To undertake a systematic review and evaluate existing literature on patients undergoing THA for acute mycobacterium tuberculosis arthritis of the hip. METHODS: A systematic review of electronic databases of PubMed, EMBASE, Scopus, Web of Science and Cochrane Library was performed on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The search focused on "arthroplasty in cases with tuberculosis of hip joint" since inception of databases until July 2023. Data on patient demographics, clinical characteristics, treatment administered, surgical interventions and outcome, as reported in the included studies, were recorded. Median (range) and mean (standard deviation) were used to summarise the data for continuous variables (as reported in the original studies); and frequency/percentage was employed for categorical variables. Available data on Harris hip scores and complications were statistically pooled using random-effects meta-analysis or fixed-effect meta-analysis, as appropriate RESULTS: Among a total of 1695 articles, 15 papers were selected for qualitative summarisation and 12 reporting relevant data were included for proportional meta-analysis. A total of 303 patients (mean age: 34 to 52 years; mean follow-up: 2.5 to 10.5 years) were included in our systematic review. In a majority of included studies, postero-lateral approach and non-cemented prosthesis were employed. Fourteen studies described a single-staged procedure in the absence of sinus, abscess and tubercular infection syndrome (TIS). All surgeries were performed under cover of prolonged course of multi-drug anti-tubercular regimen. The mean Harris hip score (HHS) at final follow-up was 91.36 [95% confidence interval (CI): 89.56-93.16; I2:90.44%; p