Hip Surgery in Quiescent or Active Tubercular Hip Arthritis; Is Reactivation Risk Really a Matter.

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Abstract

10. J Bone Miner Res. 2021 Jul;36(7):1316-1325. doi: 10.1002/jbmr.4289. Epub 2021 Mar 30. Bone microarchitecture in patients with autoimmune hepatitis. Schmidt C(1)(2), Stürznickel J(1), Strahl A(2), Oheim R(1)(3), Weiler-Normann C(3)(4), Sebode M(4), Barvencik F(1)(3), Lohse AW(3)(4), Schinke T(1), Amling M(1)(3), Schramm C(3)(4), Rolvien T(1)(2). Author information: (1)Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. (2)Division of Orthopaedics, Department of Trauma and Orthopaedic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. (3)Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. (4)1st Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. In patients with autoimmune hepatitis (AIH), osteoporosis represents a common extrahepatic complication, which we recently showed by an assessment of areal bone mineral density (aBMD) via dual-energy x-ray absorptiometry (DXA). However, it is well established that bone quality and fracture risk does not solely depend on aBMD, but also on bone microarchitecture. It is currently not known whether AIH patients exhibit a site-specific or compartment-specific deterioration in the skeletal microarchitecture. In order to assess potential geometric, volumetric, and microarchitectural changes, high-resolution peripheral quantitative computed tomography (HR-pQCT) measurements were performed at the distal radius and distal tibia in female patients with AIH (n = 51) and compared to age-matched female healthy controls (n = 32) as well as to female patients with AIH/primary biliary cholangitis (PBC) overlap syndrome (n = 25) and female patients with PBC alone (PBC, n = 36). DXA at the lumbar spine and hip, clinical characteristics, transient elastography (FibroScan) and laboratory analyses were also included in this analysis. AIH patients showed a predominant reduction of cortical thickness (Ct.Th) in the distal radius and tibia compared to healthy controls (p