Bone adhesive with temporally-synchronized degradation for enhanced osteointegration.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Competing interests: The authors declare no competing interests. 3. Pediatr Radiol. 2020 Jul;50(8):1041-1048. doi: 10.1007/s00247-020-04648-7. Epub 2020 Mar 10. Radiographic timelines for pediatric healing fractures: a systematic review. Messer DL(1)(2), Adler BH(3)(4), Brink FW(3)(5), Xiang H(6), Agnew AM(7). Author information: (1)Department of Biomedical Education and Anatomy,Division of Anatomy,College of Medicine, The Ohio State University, Columbus, OH, USA. dianamesser@gmail.com. (2)Skeletal Biology Research Lab, School of Health and Rehabilitation Sciences, The Ohio State University, 2066 Graves Hall, 333 W. 10th Ave., Columbus, OH, 43210, USA. dianamesser@gmail.com. (3)College of Medicine, The Ohio State University, Columbus, OH, USA. (4)Department of Radiology, Nationwide Children's Hospital, Columbus, OH, USA. (5)Center for Family Safety and Healing,, Nationwide Children's Hospital, Columbus, OH, USA. (6)Center for Pediatric Trauma Research & Center for Injury Research and Policy, Nationwide Children's Hospital, Columbus, OH, USA. (7)Skeletal Biology Research Lab, School of Health and Rehabilitation Sciences, The Ohio State University, 2066 Graves Hall, 333 W. 10th Ave., Columbus, OH, 43210, USA. Skeletal fractures, a common injury in physically abused children, often go undetected and untreated for significant lengths of time and are sometimes incidentally discovered radiographically. Our objective was to review current literature for scientific studies of pediatric fracture healing with associated timelines. We conducted a search of Embase, EBSCOhost, MEDLINE (PubMed), and Web of Science for literature published from the earliest available up to August 2018. We evaluated the included articles for quality, with consideration for use in clinical and forensic settings. Of a total of 313 full-text articles evaluated, 10 met study inclusion criteria. The patient age range among studies was 0-17 years, with children younger than 1 year included in the majority of studies. The fracture locations included in studies were primarily fractures of the upper limb and pectoral girdle, followed by fractures of the lower limb. The radiographic features of healing varied greatly among the studies. Timelines of common fracture healing variables differed significantly among studies. Scientific, radiographic studies of pediatric fracture healing are limited. Gaps in knowledge regarding fracture healing highlight the need for future research and validation studies. Fracture healing timelines derived from existing timelines should be used with caution. DOI: 10.1007/s00247-020-04648-7