Prognostic Significance of Survivin Expression in Osteosarcoma Patients: A Meta-Analysis.

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Abstract

[Indexed for MEDLINE] 14. Jt Dis Relat Surg. 2024 Jan 1;35(1):130-137. doi: 10.52312/jdrs.2023.1289. Epub 2023 Nov 23. Evaluation of the factors affecting survival and local recurrence in thigh soft tissue sarcomas. Yıldırım S(1), Çiftdemir M, Ustabaşıoğlu FE, Üstün F, Usta U. Author information: (1)Lüleburgaz Devlet Hastanesi Ortopedi ve Travmatoloji Kliniği, 39750 Lüleburgaz, Kırklareli, Türkiye. drsavasyldrm@gmail.com. OBJECTIVES: The aim of this study was to evaluate the factors affecting local recurrence and survival in patients with soft-tissue sarcomas located in the thigh. PATIENTS AND METHODS: This retrospective cross-sectional study evaluated 41 soft tissue sarcoma patients (21 males, 20 females; mean age: 57.9±13.7 years; range, 18 to 90 years) with thigh involvement between January 2010 and December 2020. All surgical intervention was performed by one surgeon with an experience of 15 years in orthopedic oncologic surgery. Epidemiological, radiological, histopathological, and metabolic features, as well as surgical and oncological treatments and prognoses, were assessed. The data was statistically analyzed to determine factors affecting local recurrence and survival in these cases, staged using Enneking and the American Joint Committee on Cancer classifications. RESULTS: Liposarcomas were the most common type of tumor (39%), followed by undifferentiated pleomorphic sarcomas (32%). Tumors >10 cm were associated with decreased survival rates. High-grade tumors, tumor necrosis, Ki-67 index >20%, and positive surgical margins were also associated with lower survival rates. Metastatic patients had significantly lower survival rates. Local recurrence was significantly more frequent in patients with positive surgical margins. Survival rates were significantly lower in metastatic patients. CONCLUSION: There are many factors that affect local recurrence and survival of soft tissue sarcomas. The size of the mass, the presence of necrosis, a high Ki-67 index, positive surgical margins, and the presence of metastasis are the main factors that should be taken into consideration. DOI: 10.52312/jdrs.2023.1289 PMCID: PMC10746889