KPNA2 promotes osteosarcoma progression by regulating the alternative splicing of DDX3X mediated by YBX1.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Competing interests: LC, KJ, YY, YP, XC, QP, WY, ZZ, ZS, and WW report no conflicts of interest. VT BA reports research grants from Polaris, Pfizer, Merck, Tracon Pharma, GlaxoSmithKline; consulting fees from Bayer, Cytokinetics Inc., Deciphera Pharmaceuticals, Daiichi Sankyo, EcoR1, Advenchen, Putnam, Salarius Pharmaceuticals, Boxer Capital LLC, Acuta Capital Partners LLC, Aadi Biosciences, Race Oncology Limited, Hinge Bio, Inc., and Kronos Bio, Inc.; honoraria for educational talks from Iteration Therapeutics, Inc. and Total Health Conference; fees for participation in Data/Safety Advisory Boards for Apexigen, Daiichi Sankyo, Epizyme, Bayer, PTC Therapeutics, Aadi Biosciences, Boehringer Ingelheim, Agenus, Regeneron Pharmaceuticals, Advenchen, and Curtis; and speaking fees from Caris, Janssen, Lilly, Target Oncology, Bionest Partners, and Intellisphere LLC. Ethical approval: The research was carried out in accordance with the principles outlined in the Declaration of Helsinki. The Animal Use and Care Committees at Tongji Medical College, Huazhong University of Science and Technology approved approval for the research (IACUC Number: [2023] 3790). Consent for publication: All subjects signed a written informed consent. 14. Instr Course Lect. 2004;53:639-44. The biopsy. Scarborough MT(1). Author information: (1)Department of Orthopedic Surgery, University of Florida, Gainesville, Florida, USA. The biopsy of a musculoskeletal lesion is an important event, the outcome of which guides patient management and helps determine patient prognosis. The principles of biopsy include complete radiologic staging before the biopsy, thorough prebiopsy planning including consultation with the pathologist and radiologist, determining the most appropriate method of biopsy (fine needle, core needle, open surgical biopsy), placing the biopsy tract appropriately, and making sure the biopsy tract can be removed at the time of resection, avoiding contamination of uninvolved structures, avoiding transverse incisions, preventing pathologic fracture, handling biopsy tissue appropriately, and considering referral before biopsy. The common errors of biopsy include sampling errors, postbiopsy hematomas, the use of transverse incisions, tumor implantation, and the treatment of an unsuspected sarcoma with prophylactic fixation. Thoughtful prebiopsy planning and careful completion of the biopsy can result in an expedient and accurate diagnosis. If the treating physician lacks significant expertise in performing biopsy and management of patients with musculoskeletal lesions, then referral to a musculoskeletal oncologist before biopsy should be considered.