Glutamine Promotes Rotator Cuff Healing by Ameliorating Age-Related Osteoporosis.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Disclosure: No external funding was received for this work. The Disclosure of Potential Conflicts of Interest forms are provided with the online version of the article ( http://links.lww.com/JBJS/I517 ). 19. Adv Sci (Weinh). 2024 Aug;11(31):e2308443. doi: 10.1002/advs.202308443. Epub 2024 Jun 23. Bioactive Patch for Rotator Cuff Repairing via Enhancing Tendon-to-Bone Healing: A Large Animal Study and Short-Term Outcome of a Clinical Trial. Kang Y(1)(2), Wang L(1)(2), Zhang S(3), Liu B(4), Gao H(1)(2), Jin H(1)(2), Xiao L(5), Zhang G(1)(2), Li Y(3), Jiang J(1)(2), Zhao J(1)(2). Author information: (1)Department of Sports Medicine, Department of Orthopedics, Shanghai Institute of Microsurgery on Extremities, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai, 200233, China. (2)Regenerative Sports Medicine and Translational Youth Science and Technology Innovation Workroom, Shanghai Jiao Tong University School of Medicine, No. 600 Yishan Road, Shanghai, 200233, China. (3)Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China. (4)Bioarticure Medical Technology (Shanghai) Co., Ltd, No.81-82, Zuchongzhi Road, Pudong, Shanghai, 200120, China. (5)School of Mechanical, Medical and Process Engineering, Center of Biomedical Technology, Queensland University of Technology, Brisbane, 4059, Australia. Tissue engineering has demonstrated its efficacy in promoting tissue regeneration, and extensive research has explored its application in rotator cuff (RC) tears. However, there remains a paucity of research translating from bench to clinic. A key challenge in RC repair is the healing of tendon-bone interface (TBI), for which bioactive materials suitable for interface repair are still lacking. The umbilical cord (UC), which serves as a vital repository of bioactive components in nature, is emerging as an important source of tissue engineering materials. A minimally manipulated approach is used to fabricate UC scaffolds that retain a wealth of bioactive components and cytokines. The scaffold demonstrates the ability to modulate the TBI healing microenvironment by facilitating cell proliferation, migration, suppressing inflammation, and inducing chondrogenic differentiation. This foundation sets the stage for in vivo validation and clinical translation. Following implantation of UC scaffolds in the canine model, comprehensive assessments, including MRI and histological analysis confirm their efficacy in inducing TBI reconstruction. Encouraging short-term clinical results further suggest the ability of UC scaffolds to effectively enhance RC repair. This investigation explores the mechanisms underlying the promotion of TBI repair by UC scaffolds, providing key insights for clinical application and translational research. © 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH. DOI: 10.1002/advs.202308443 PMCID: PMC11336973