Controversies in Oncologic Pediatric 
Limb Salvage.

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Abstract

[Indexed for MEDLINE] 7. Adv Exp Med Biol. 2020;1257:13-29. doi: 10.1007/978-3-030-43032-0_2. Limb Salvage and Reconstruction Options in Osteosarcoma. Grinberg SZ(1), Posta A(2), Weber KL(3), Wilson RJ(4). Author information: (1)Medical Student, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA. (2)Undergraduate Student, Swarthmore College, Swarthmore, PA, USA. (3)Penn Medicine Department of Orthopaedic Surgery, Philadelphia, PA, USA. (4)Penn Medicine Department of Orthopaedic Surgery, Philadelphia, PA, USA. Robert.wilson3@uphs.upenn.edu. Advances in chemotherapy, sophisticated imaging, and surgical techniques over the last few decades have allowed limb-salvage surgery (LSS) to become the preferred surgical treatment for bone sarcomas of the extremities. The goal of LLS is to maximize limb functionality to allow for the maintenance of quality of life without compromising overall survival and tumor local recurrence rates. Today, limb-salvage procedures are performed on 80-95% of patients with extremity osteosarcoma, and the 5-year survival rate in extremity osteosarcoma patients is now 60-75%.This chapter will focus on LSS for extremity osteosarcoma. Common types of surgical reconstruction techniques including endoprostheses, intercalary or osteoarticular allografts, vascularized fibular autografts, and allograft prosthetic composites (APC), and their complications such as infection, local recurrence, graft fracture, implant failure, and nonunion will be discussed in detail. Anatomic locations of lesions discussed include the proximal femur, distal femur, proximal tibia, distal tibia, proximal humerus, distal humerus, and forearm bones. DOI: 10.1007/978-3-030-43032-0_2