ADT with SBRT versus SBRT alone for hormone-sensitive oligorecurrent prostate cancer (RADIOSA): a randomised, open-label, phase 2 clinical trial.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declaration of interests The Division of Radiation Oncology of the European Institute of Oncology IRCCS received research funding from the Italian Association for Cancer Research, Fondazione Istituto Europeo di Oncologia-Centro Cardiologico Monzino, Accuray, and Ion Beam applications. NF has received honoraria for consulting, an advisory role, speaker bureau, travel, or research grants from Merck Sharp & Dohme, Merck, Novartis, AstraZeneca, Roche, Menarini, Daiichi Sankyo, GSK, Gilead, Sysmex, Veracyte, Sakura, Leica Biosystems, Lilly, and Pfizer. These companies had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. BAJ-F received speakers fees from Bayer, Accuray, Astellas, IBA, Ipsen, AstraZeneca, Tecnologie avanzate, Recordati, and Novartis. BAJ-F participated in the advisory boards of Accuray, Bayer, and Seagen, all outside the current project. CT received travel support and honorarium from Boston Scientific, Diffusion Pharmaceuticals, and Vision RT. CT participated in advisory boards for Bayer, Telix, Lantheus, and Molli Surgical and receives royalties from Wolter Kluwer, all outside the current project. All other authors declare no competing interests. 13. Multimed Man Cardiothorac Surg. 2024 May 3;2024. doi: 10.1510/mmcts.2024.005. Manubriectomy made easy. Mughal AZ(1), El-Zeki A(1), Oliemy A(1), Habib AM(1). Author information: (1)Cardiothoracic Surgery Department, New Cross Hospital, Royal Wolverhampton NHS Foundation Trust, Wolverhampton, United Kingdom. Bone metastasis is the most common form of distant metastasis encountered within the breast cancer population. Surgical resection of bone metastases is a curative treatment option in patients who present with an isolated solitary lesion and no other associated disease. This decision is typically made following a multidisciplinary discussion. Patients can also be put forward for surgical excision of bone metastases following inadequate response to chemotherapy or radiotherapy.  With tumours located in the manubrium of the sternum, surgery serves not only to resect the bone metastasis but to provide suitable chest wall reconstruction. The goal of this approach is to maintain the structural and bony stability of the chest wall as well as that of associated structures, e.g. rib insertion or articulation of the shoulder girdle. A widely utilized approach involves excising the area of metastasis within the manubrium followed by implanting a bone cement prosthesis. Titanium plates are used to fix the bone prosthesis to the sternal body inferiorly and to the remainder of the manubrium superiorly.  We present a step-by-step video tutorial for performing a lower hemi-manubriectomy in a patient with triple-negative breast cancer. Our goal is to describe the fundamental principles and surgical techniques used to perform this procedure followed by the postoperative outcomes. © The Author 2024. Published by MMCTS on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. DOI: 10.1510/mmcts.2024.005