Inflammatory diseases causing joint and bone destruction: rheumatoid arthritis and hemophilic arthropathy.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: The authors declare that they have no conflicts of interest. 13. Haemophilia. 2006 Jul;12(4):337-44. doi: 10.1111/j.1365-2516.2006.01285.x. The haemophilic ankle. Rodriguez-Merchan EC(1). Author information: (1)La Paz University Hospital, Madrid, Spain. rmerchan@arrakis.es Radiation synoviorthesis is a very effective procedure that decreases both the frequency and the intensity of recurrent ankle bleeds related to ankle synovitis. The procedure should be performed as soon as possible to minimize the degree of articular cartilage damage. It can also be used in patients with inhibitors with minimal risk of complications. On average, the efficacy of the procedure ranges from 76% to 80%, and can be performed at any age. The procedure slows the cartilaginous damage which intra-articular blood tends to produce in the long term. After 30 years of using radiation synovectomy worldwide, no damage has been reported in relation to the radioactive materials. Radiation synovectomy is currently the preferred procedure when radioactive materials are available; however, chemical synoviorthesis is an effective alternative method if radioactive materials are not available. Personal experience and the general recommendation among orthopaedic surgeons and haematologists is that when three early consecutive synoviorthesis (repeated every 3 months) fail to halt synovitis, a surgical synovectomy (open or by arthroscopy) should be immediately considered. For advanced haemophilic arthropathy of the ankle, the best solution is an ankle arthrodesis. Primary prophylaxis and radioactive synoviorthesis are the best ways that we have today of protecting against haemophilic synovitis and arthropathy of the ankle joint. DOI: 10.1111/j.1365-2516.2006.01285.x