Peripheral Nerve Injury.

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Abstract

Conflict of interest statement: Disclosure: Mustafa Nadi declares no relevant financial relationships with ineligible companies. Disclosure: Waleed Dabbas declares no relevant financial relationships with ineligible companies. Disclosure: Joe Das declares no relevant financial relationships with ineligible companies. 3. Neuroanatomy, Neurapraxia(Archived). Biso GMNR(1), Munakomi S(2). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026 Jan–. 2022 Oct 24. Author information: (1)Albert Einstein Medical Center (2)Kathmandu University Neuropraxia is the mildest form of traumatic peripheral nerve injury. It is characterized by focal segmental demyelination at the site of injury without disruption of axon continuity and its surrounding connective tissues. This condition results in blockage of nerve conduction and transient weakness or paresthesia. Complete recovery is the expectation upon spontaneous remyelination—peripheral nerve injury (PNI) organizes into five categories that clinicians use today (see Image. Neurapraxia). Sunderland stratified and expanded Seddon's (1943) classification into Grade I, refers focal segmental demyelination; Grade II refers to damaged axon with intact endoneurium; Grade III refers to damaged axon and endoneurium with intact perineurium; Grade IV refers to the damaged axon, endoneurium, and perineurium with intact epineurium; and Grade V refers to complete transection (see Table. Seddon and Sunderland Classification of Nerve Injury). Some authors also describe a sixth-degree peripheral nerve injury, which refers to the mixed pathology of injury. Neuropraxia, and PNI in general, can be secondary to trauma from sports, accidents, or improper positioning. Injury to nerves results in motor or sensory loss, pain, or a combination of these, leading to significant morbidity or functional impairment.  Copyright © 2026, StatPearls Publishing LLC.