Synthesis and preclinical evaluation of [(18)F]AlF-NOTA-Asp(2)-PEG(2)-JR11 as a novel antagonist radioligand for PET imaging of somatostatin receptor.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declarations. Consent for publication: All the authors approved the publication of the article. Competing interests: No other potential conflicts of interest relevant to this article exist. Ethics approval: The study was approved by the Nanfang Hospital Animal Ethics Committee at the Southern Medical University (Application No: IACUC-LAC-20230911-002). Informed consent: Not applicable. 17. ACS Biomater Sci Eng. 2021 Dec 13;7(12):5727-5738. doi: 10.1021/acsbiomaterials.1c00509. Epub 2021 Nov 22. Prefabricated 3D-Printed Tissue-Engineered Bone for Mandibular Reconstruction: A Preclinical Translational Study in Primate. Cao SS(1), Li SY(1)(2), Geng YM(3), Kapat K(1), Liu SB(1), Perera FH(4), Li Q(5), Terheyden H(6), Wu G(7), Che YJ(8), Miranda P(4), Zhou M(1). Author information: (1)Department of Oral and Maxillofacial Surgery, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou 510182, China. (2)Department of Oral and Maxillofacial Surgery/Pathology, Amsterdam UMC and Academic Center for Dentistry Amsterdam (ACTA), Amsterdam Movement Science, de Boelelaan, Vrije Universiteit Amsterdam 1117, Amsterdam, The Netherlands. (3)Department of Stomatology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. (4)Department of Mechanical, Energy and Materials Engineering, University of Extremadura, Industrial Engineering School, Avda. de Elvas s/n, 06006 Badajoz, Spain. (5)Hangzhou Jiuyuan Gene Engineering Co., Ltd., Hangzhou 3100018, China. (6)Department of Oral and Maxillofacial Surgery, Red Cross Hospital, Kassel 34117, Germany. (7)Department of Oral Implantology and Prosthetic Dentistry, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam 1117, The Netherlands. (8)Department of Anesthesia, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China. The advent of three dimensionally (3D) printed customized bone grafts using different biomaterials has enabled repairs of complex bone defects in various in vivo models. However, studies related to their clinical translations are truly limited. Herein, 3D printed poly(lactic-co-glycolic acid)/β-tricalcium phosphate (PLGA/TCP) and TCP scaffolds with or without recombinant bone morphogenetic protein -2 (rhBMP-2) coating were utilized to repair primate's large-volume mandibular defects and compared efficacy of prefabricated tissue-engineered bone (PTEB) over direct implantation (without prefabrication). 18F-FDG PET/CT was explored for real-time monitoring of bone regeneration and vascularization. After 3-month's prefabrication, the original 3D-architecture of the PLGA/TCP-BMP scaffold was found to be completely lost, while it was properly maintained in TCP-BMP scaffolds. Besides, there was a remarkable decrease in the PLGA/TCP-BMP scaffold density and increase in TCP-BMP scaffolds density during ectopic (within latissimus dorsi muscle) and orthotopic (within mandibular defect) implantation, indicating regular bone formation with TCP-BMP scaffolds. Notably, PTEB based on TCP-BMP scaffold was successfully fabricated with pronounced effects on bone regeneration and vascularization based on radiographic, 18F-FDG PET/CT, and histological evaluation, suggesting a promising approach toward clinical translation. DOI: 10.1021/acsbiomaterials.1c00509 PMCID: PMC8672350