Fracture related infection and sepsis in orthopedic trauma: A review.

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Abstract

[Indexed for MEDLINE] 11. Orthop Nurs. 2023 Sep-Oct 01;42(5):312-316. doi: 10.1097/NOR.0000000000000972. Overview of Antibiotic Prophylaxis in Orthopaedic and Cardiac Procedures. Karapetyan K(1)(2)(3)(4), Mei S(1)(2)(3)(4), Choudhury A(1)(2)(3)(4), Cottreau J(1)(2)(3)(4). Author information: (1)Kristina Karapetyan, PharmD, PGY-2 Ambulatory Care Pharmacy Resident, Captain James A. Lovell Federal Health Care Center, North Chicago, IL. (2)Sally Mei, PharmD, Clinical Pharmacy Practitioner, Captain James A. Lovell Federal Health Care Center, North Chicago, IL. (3)Aeman Choudhury, PharmD, BCACP, Clinical Pharmacy Practitioner, Captain James A. Lovell Federal Health Care Center, North Chicago, IL. (4)Jessica Cottreau, PharmD, BCPS, BCIDP, Chair and Associate Professor, Department of Pharmacy Practice, Rosalind Franklin University of Medicine and Science, North Chicago, IL. Antibiotic prophylaxis (AP) in surgical procedures is commonly used to prevent infections that may occur after operations. There are multiple factors that can contribute to increased risk of postsurgical complications that include prolonged hospitalization, reoperation, and readmissions. One of the strategies of decreasing the risk of bacterial contamination and developing infections is preprocedural antibiotic administration. When selecting an appropriate antibiotic, it is important to take into account surgery type and patient's characteristics which would also impact timing of administration and prophylaxis duration. Although surgical AP is significant for avoiding bacterial complications, it is also associated with some drawbacks such as increased antibiotic resistance and development of adverse reactions. Therefore, it is important to assess risks and benefits and select the most appropriate antibiotic regimen before initiating AP. Copyright © 2023 by National Association of Orthopaedic Nurses. DOI: 10.1097/NOR.0000000000000972