Mucopolysaccharidosis Type IVA.

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Abstract

7. Arch Dis Child. 2025 Apr 17;110(5):341-346. doi: 10.1136/archdischild-2024-327891. Management of Legg-Calve-Perthes disease: a scoping review with advice on initial management. Beni R(1), Hussain SA(2)(3), Monsell F(4), Gelfer Y(5)(2). Author information: (1)City St. George's University of London, London, UK. (2)St George's University Hospitals NHS Foundation Trust, London, UK. (3)Royal London Hospital Barts Health NHS Trust, London, UK. (4)Bristol Royal Hospital for Children, Bristol, UK. (5)City St. George's University of London, London, UK yaelgelfer@gmail.com. BACKGROUND: Legg-Calve-Perthes disease (LCPD) is a developmental disorder causing avascular necrosis of the femoral head in children, with long-term consequences that can extend into adulthood. Early diagnosis and management in primary care are crucial but challenging. AIM: This review aims to provide a concise overview of the presentation, differential diagnosis and management of LCPD, offering practical guidance for primary healthcare professionals. METHOD: Recent literature and expert opinions were reviewed to summarise the epidemiology, diagnosis and current management of LCPD. RESULTS: LCPD commonly presents as a painless limp in children aged between 2 and 14 years, with the diagnosis based on the clinical features and radiographic abnormalities. Management is individualised and includes non-operative care to surgery, which attempts to correct anatomical abnormalities and therefore delay the onset of osteoarthritis. The review highlights the importance of primary care in early detection, appropriate referral and interim management. CONCLUSION: LCPD is a rare condition that can lead to long-term disability, affecting a child's physical, mental and social development, often presenting as a painless limp. Diagnosis typically involves plain radiographs, with MRI or hip joint arthrography providing additional details for management, which may include both non-surgical (eg, physiotherapy) and surgical options. Early recognition by primary care providers is crucial for timely referral to orthopaedic services, along with interim support through physiotherapy, pain management and access to mental health and educational resources. © Author(s) (or their employer(s)) 2025. No commercial re-use. See rights and permissions. Published by BMJ Group. DOI: 10.1136/archdischild-2024-327891