[New principles of using biodegradable implants in the treatment of fractures].

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Abstract

[Indexed for MEDLINE] 7. BMC Oral Health. 2025 Dec 1;26(1):349. doi: 10.1186/s12903-025-07385-1. How do infrared and near-infrared lasers influence autophagy and alveolar bone remodeling in rats during orthodontic tooth retention? An Y(1), Shen W(2), An L(3), Li Z(1), Wang J(1), Wu Y(1), Gong G(4), Li J(5), Liu Q(6). Author information: (1)Shanxi Medical University School and Hospital of Stomatology; Shanxi Bethune Hospital, No.99 Longcheng Street, Taiyuan, Shanxi, 030001, China. (2)Department of Stomatology, Sandun Branch of Zhejiang Hospital, Hangzhou, Zhejiang, China. (3)Department of Operation, Shanxi Cancer Hospital, Taiyuan, Shanxi, China. (4)Department of Stomatology, Yaboyi Dental Clinic, Hangzhou, Zhejiang, China. (5)Department of Stomatology, Jincheng People's Hospital, Jincheng, Shanxi, China. (6)Shanxi Medical University School and Hospital of Stomatology; Shanxi Bethune Hospital, No.99 Longcheng Street, Taiyuan, Shanxi, 030001, China. liuqingmei2006@sina.com. BACKGROUND: Few studies have explored the association between autophagy and osteogenesis during orthodontic retention. This study compared the impact of 660-nm infrared (IR) and 808-nm near-infrared (NIR) lasers on the autophagy and alveolar bone remodeling in rats during orthodontic tooth retention. METHODS: Seventy-five rats were divided into three groups: Group A (control), Group B (660 -nm IR irradiation), and Group C (808-nm NIR irradiation). A 50-g force was applied by ligating a nickel-titanium coil spring from the left upper first molar to the incisors to move the molar in a mesial direction for 3 weeks, with weekly force applications. Post-force application, a fixed retainer was used to maintain the molar-incisor distance on days 1, 7, 14, 21, and 28, establishing a retention model; 660-nm and 808-nm lasers (100 mW, 9 mm spot, 5 J/cm²) were directed to the buccal and palatal gingiva at the mid-root height of the first molar for 30 s every 3 days. After removal of the fixed retainers, the rats underwent a 3-day recovery phase before euthanasia on days 4, 10, 17, 24, and 31 post-irradiation. The relapse rates of the molar were assessed by 3Shape scanning, alveolar bone density using micro-computed tomography, and periodontal tissue remodeling through histological staining at the tensile zone of the molar. RESULTS: With longer retention, the relapse rate and the number of tartrate-resistant acid phosphatase (TRAP)-positive cells decreased. At the same time, alveolar bone density and autophagy protein Beclin-I/osteoprotegerin (OPG) expression increased, peaking at 28 days (P