Imaging of intraarticular masses.

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Abstract

[Indexed for MEDLINE] 20. J Neurosurg Spine. 2024 Mar 15;40(6):782-789. doi: 10.3171/2024.1.SPINE231184. Print 2024 Jun 1. Therapeutic approaches for spinal synovial sarcoma: a comprehensive review of the literature. Zamarud A(1), Shahnoor S(2), Maryyum A(3), Khan AM(3), Hassan KM(4), Ijaz A(5), Sayed R(6), Yoo K(1), Park DJ(1), Chang SD(1). Author information: (1)1Department of Neurosurgery, Stanford University, School of Medicine, Stanford, California. (2)2Department of Surgery, Dow University of Health Sciences, Karachi, Pakistan. (3)3Department of Surgery, Ayub Medical College, Abbottabad, Pakistan. (4)4Department of Surgery, King Edward Medical University, Lahore, Pakistan. (5)5Department of Surgery, Rahbar Medical & Dental College, Lahore, Pakistan; and. (6)6Department of Neurosurgery, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York. OBJECTIVE: Synovial sarcoma (SS) is a relatively rare type of soft-tissue sarcoma that is commonly treated with surgery, radiation, chemotherapy, and palliative care. Stereotactic radiosurgery (SRS) is an emerging approach that shows promise in treating CNS conditions, but it has not been studied for SS. The authors present a systematic review that explores the effectiveness of different treatments, with a focus on SRS, for managing spinal SS. METHODS: A systematic PubMed search was conducted that covered studies from 1964 to 2022, yielding 70 relevant studies. Inclusion criteria encompassed primary and metastatic spinal SS, various treatment modalities, patient age 17 years or older, English-language studies, retrospective series, and case reports. Based on these criteria, 26 studies were included in this review and 44 were excluded. RESULTS: Of the included studies, 15 patients from 9 studies were treated with surgical intervention followed by both conventional radiotherapy (RT) and chemotherapy, 10 patients from 10 studies were treated with surgery followed by RT, 5 studies comprising 8 patients were exclusively treated with surgery, 5 cases in 3 studies were treated with surgery plus concomitant chemotherapy, 4 patients in 2 studies were treated with SRS, and only 1 study reported treatment without surgery and with chemotherapy and RT. The median progression-free survival and overall survival periods observed in the SRS-treated patients were 37 months and 60 months, respectively, which were higher than those of any other treatment method or combination used. CONCLUSIONS: The authors' study offers a thorough review of spinal SS treatments. They are hopeful that this will aid clinicians in informed decision-making for better patient outcomes. DOI: 10.3171/2024.1.SPINE231184