VTE rates and risk factors in major trauma patients.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: FNA reports a relationship with Actelion that includes funding grants. FNA reports a relationship with Bayer that includes funding grants. FNA reports a relationship with Sanofi that includes funding grants. FNA reports a relationship with Daiichi-Sankyo that includes funding grants. FNA reports a relationship with American Society of Hematology that includes personal honorarium. 12. Orthop Clin North Am. 2010 Apr;41(2):273-80. doi: 10.1016/j.ocl.2010.02.001. DVT prophylaxis in total joint reconstruction. Sheth NP(1), Lieberman JR, Della Valle CJ. Author information: (1)Department of Orthopaedic Surgery, Rush University, Midwest Orthopaedics, 1725 West Harrison Street, Chicago, IL 60612, USA. Deep venous thrombosis (DVT) is the end result of a complex interaction of events including the activation of the clotting cascade in conjunction with platelet aggregation. Patients undergoing major lower extremity orthopedic surgery, especially total joint arthroplasty (TJA), are at high risk for developing a postoperative DVT or a subsequent pulmonary embolus. Venous thromboembolic (VTE) prophylaxis, most commonly pharmacologic prophylaxis, has become the standard of care for patients undergoing elective TJA. However, the controversy between the efficacy of VTE prophylaxis and the increased risk for bleeding in the postoperative period continues to exist. This review addresses the controversy underlying VTE prophylaxis by outlining 2 guidelines and demonstrating the pros and cons of different DVT prophylaxis regimens based on the available evidence-based literature. Copyright 2010 Elsevier Inc. All rights reserved. DOI: 10.1016/j.ocl.2010.02.001