Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: The authors declare that they have no competing interests. 2. J Bone Joint Surg Br. 2012 Jan;94(1):10-5. doi: 10.1302/0301-620X.94B1.28047. Current concepts in osteolysis. Ollivere B(1), Wimhurst JA, Clark IM, Donell ST. Author information: (1)Norfolk & Norwich University Hospital, Colney Lane, Norwich NR4 7UY, UK. ben.ollivere@nuh.nhs.uk The most frequent cause of failure after total hip replacement in all reported arthroplasty registries is peri-prosthetic osteolysis. Osteolysis is an active biological process initiated in response to wear debris. The eventual response to this process is the activation of macrophages and loss of bone. Activation of macrophages initiates a complex biological cascade resulting in the final common pathway of an increase in osteolytic activity. The biological initiators, mechanisms for and regulation of this process are beginning to be understood. This article explores current concepts in the causes of, and underlying biological mechanism resulting in peri-prosthetic osteolysis, reviewing the current basic science and clinical literature surrounding the topic. DOI: 10.1302/0301-620X.94B1.28047