Corticosteroids for periorbital and orbital cellulitis.

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Abstract

[Indexed for MEDLINE] Conflict of interest statement: EK: none known.
SM: none known.
PP: none known.
YAR: none known.
SS: none known.
PG: Has received grants from the Canadian Institute of Health Research (CIHR) and The Hospital for Sick Children; nonfinancial support from the EBMLive Steering Committee, and the CIHR Institute of Human Development, Child and Youth Health. He is also a member of the CMAJ Open and BMJ Evidence Based Medicine Editorial Board. 10. BMC Musculoskelet Disord. 2024 Jan 17;25(1):70. doi: 10.1186/s12891-024-07187-6. Establishment and pathophysiological evaluation of a novel model of acute compartment syndrome in rats. Dong Q(#)(1)(2), Long Y(#)(1)(2)(3), Jin L(#)(1)(2), Hou G(4), Li G(1)(2), Wang T(1)(2), Jia H(1)(2), Yin Y(1)(2), Guo J(5), Ma H(6), Xu S(1)(2)(7), Zhang Y(1)(2), Hou Z(8)(9). Author information: (1)Department of Orthopaedics Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China. (2)Orthopaedic Research Institute of Hebei Province, Third Hospital of Hebei Medical University, Shijiazhuang, China. (3)Department of Orthopaedics Surgery, Baoding No.1 Central Hospital, Baoding, China. (4)WLSA Shanghai Academy, Shanghai, China. (5)Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, China. (6)Hebei Medical University, Shijiazhuang, China. (7)Department of Nephrology, Third Hospital of Hebei Medical University, Shijiazhuang, China. (8)Department of Orthopaedics Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China. drzyhou@gmail.com. (9)Orthopaedic Research Institute of Hebei Province, Third Hospital of Hebei Medical University, Shijiazhuang, China. drzyhou@gmail.com. (#)Contributed equally BACKGROUND: Researches have used intra-compartmental infusion and ballon tourniquest to create high intra-compartmental pressure in animal models of Acute Compartment Syndrome (ACS). However, due to the large differences in the modeling methods and the evaluation criteria of ACS, further researches of its pathophysiology and pathogenesis are hindered. Currently, there is no ideal animal model for ACS and this study aimed to establish a reproducible, clinically relevant animal model. METHODS: Blunt trauma and fracture were caused by the free falling of weights (0.5 kg, 1 kg, 2 kg) from a height of 40 cm onto the lower legs of rats, and the application of pressures of 100 mmHg, 200 mmHg, 300 mmHg and 400 mmHg to the lower limbs of rats using a modified pressurizing device for 6 h. The intra-compartmental pressure (ICP) and the pressure change (ΔP) of rats with single and combined injury were continuously recorded, and the pathophysiology of the rats was assessed based on serum biochemistry, histological and hemodynamic changes. RESULTS: The ΔP caused by single injury method of different weights falling onto the lower leg did not meet the diagnosis criteria for ACS (