Etiology-Based Classification of Adjacent Segment Disease Following Lumbar Spine Fusion.

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Abstract

Conflict of interest statement: Conflict of InterestGarrett K. Harada, MD, Arash J. Sayari, MD, Benjamin C. Mayo, MD, Jannat M. Khan, BS, Arya G. Varthi, MD, and Alem Yacob, MD, declare that they have no conflicts of interest. Philip K. Louie, MD, reports stock or stock options from StreaMD, outside the submitted work. Dino Samartzis, DSc, reports board or committee membership at AOSpine and International Society for the Study of the Lumbar Spine; publishing royalties from BMC Scoliosis and Spinal Disorders and Elsevier; and editorial or governing board membership from Global Spine Journal, Scoliosis and Spinal Disorders, and Spine Journal, outside the submitted work. Howard S. An, MD, reports royalties from U & I Corporation and Zimmer Biomet; stock ownership in Articular Engineering, Medyssey Inc., and Spinal Kinetics; consulting fees from Bioventus and Stryker; editorial board membership at American Journal of Orthopaedics and Spine Journal; and research support from Medyssey Inc. and SpinalCyte LLC, outside the submitted work. 4. Front Bioeng Biotechnol. 2025 Feb 19;13:1473776. doi: 10.3389/fbioe.2025.1473776. eCollection 2025. Biomechanical analysis of spinal range of motion and intervertebral disc loadings in normal and adolescent idiopathic scoliosis models. Wang H(#)(1), Ma Z(#)(2), Wu Z(3), Lin Y(4), Yu J(4), Qian X(4), Jian S(4), Sun Y(5), Wei W(6), Yu X(3), Liang Z(4)(7). Author information: (1)South China Research Center for Acupuncture and Moxibustion, Medical College of Acu - Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China. (2)College of Urban Transportation and Logistics, Shenzhen Technology University, Shenzhen, Guangdong, China. (3)The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, China. (4)Department of Tuina and Spinal Orthopaedics in Chinese Medicine, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong, China. (5)Key Laboratory of the Ministry of Education of Chronic Musculoskeletal Disease, Longhua Hospital, Spine Institute, Shanghai University of Traditional Chinese Medicine, Shanghai, China. (6)Laboratoire de Biomécanique Appliquée (UMRT24), Aix-Marseille Université/Université Gustave Eiffel, Marseille, France. (7)Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China. (#)Contributed equally OBJECTIVE: While the Lenke classification enhances our structural understanding of adolescent idiopathic scoliosis (AIS), the biomechanical implications for spinal range of motion (ROM) and intervertebral disc (IVD) loadings remain unclear. This study aims to quantitatively explore and compare these biomechanical responses in normal thoracolumbar spines and those with various curvatures of Lenke types under pure bending conditions. METHODS: The baseline thoracolumbar finite element (FE) model was derived from a comprehensive human body FE model, validated, and calibrated against spinal responses under dynamic compression and quasi-static bending conditions. Using mesh morphing, AIS models of Lenke 1, Lenke 2, Lenke 3, and Lenke 5 were established to represent their respective spinal curvatures. Pure bending moments of ±7.5 Nm in flexion-extension, lateral bending, and axial rotation were applied to both normal and AIS models. Global spinal ROM and ROM of spinal segments T1-T6, T7-T12, and L1-Sacrum were measured under each loading condition. IVD mechanical loadings, including force, moment, and VonMises stress, were also evaluated and compared across all models. RESULTS: AIS models showed higher principal ROM compared to the normal model, with Lenke 2 having the highest ROM from T1-Sacrum and Lenke 3 the highest ROM from T6-12. AIS models exhibited more asymmetry in segmental ROM, particularly in the lumbar spine during lateral bending and axial rotation. IVD mechanical loadings varied significantly between normal and AIS models, influenced by spinal curvature types. AIS models had higher secondary moments and shear forces, especially under flexion-extension. The highest stress was mostly observed in the frontal IVD regions under flexion which was greatly reduced under extension. Lateral bending caused the highest stress predominantly on the same side as the loading direction in the IVD regions. The IVDs of T6-T7 and T12-L1 showed even stress distribution under axial rotation, while the right IVD regions of L5-Sacrum sustained the highest stress under right axial rotation, and the left regions under left axial rotation. In Lenke 3 and Lenke 5 models, the right (concave) regions of the T12-L1 IVD consistently sustained higher stress levels, regardless of the loading conditions applied. CONCLUSION: This study underscores significant biomechanical differences between normal and AIS models, revealing intricate interactions within scoliotic spines and enhancing our understanding of AIS biomechanics. These insights can aid in better diagnosis, treatment planning, and prognosis. Extension-focused therapeutic exercises may reduce stress on anterior IVDs, potentially lowering the risk of low back pain or disc herniation, while careful management of rotational exercises can help minimize stress in the lower lumbar regions. Copyright © 2025 Wang, Ma, Wu, Lin, Yu, Qian, Jian, Sun, Wei, Yu and Liang. DOI: 10.3389/fbioe.2025.1473776 PMCID: PMC11880291