Orthobiologics in Hand Surgery.

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Abstract

[Indexed for MEDLINE] 8. S D Med. 2024 Nov;77(11):516-525. Carpal Tunnel, Trigger Finger, and Spinal Stenosis: The Rest of the Story. Rath J(1)(2), Durkin V(3)(4), Van Demark RE Jr(5)(6). Author information: (1)University of South Dakota Sanford School of Medicine. (2)Orthopedic Surgery Residency Program, University of Oklahoma College of Medicine. (3)Pathology Residency Program, University of South Dakota Sanford School of Medicine. (4)Surgical Pathology Fellowship Program, University of South Dakota Sanford School of Medicine. (5)Sanford Orthopedics and Sports Medicine, Sioux Falls, South Dakota. (6)Department of Surgery, University of South Dakota Sanford School of Medicine. Amyloidosis is a deadly systemic disease in which misfolded proteins accumulate in human tissue eventually leading to morbid dysfunction in multiple organ systems. The prognosis of untreated amyloidosis is poor. Orthopedic manifestations of amyloidosis include carpal tunnel syndrome (CTS), trigger digit, distal biceps tendon rupture, rotator cuff disease, and lumbar spinal stenosis. These orthopedic conditions are early red flags for systemic amyloidosis. CTS is often the earliest manifestation and can precede the disease by over four years. With the advent of medications that can slow the progression of amyloidosis, particularly in the early stages of the disease, it is imperative to diagnose amyloidosis early on. Both primary care physicians and orthopedic surgeons can recognize the various orthopedic conditions associated with amyloidosis and play a vital role in early disease detection. Awareness of the musculoskeletal presentation of systemic amyloidosis can lead to earlier detection and treatment that can delay the progression of the disease. Copyright© South Dakota State Medical Association.