Efficacy of imatinib mesylate for the treatment of locally advanced and/or metastatic tenosynovial giant cell tumor/pigmented villonodular synovitis.

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Abstract

[Indexed for MEDLINE] 19. Case Rep Infect Dis. 2021 Aug 14;2021:5523212. doi: 10.1155/2021/5523212. eCollection 2021. Diffuse-Type Tenosynovial Giant Cell Tumor of the Knee with Concurrent Polymicrobial Infection (Klebsiella oxytoca and Group B Streptococcus). Marshall JH(1), Skedros JG(1), Campana CF(2), Seibert AM(3). Author information: (1)Utah Orthopaedic Specialists and LDS Hospital, Salt Lake City, UT, USA. (2)Intermountain Healthcare Department of Pathology, Salt Lake City, UT, USA. (3)University of Utah Division of Infectious Diseases and Intermountain Healthcare Division of Infectious Diseases, Salt Lake City, UT, USA. Tenosynovial giant cell tumors (TGCT) are a rare class of benign proliferative tumors that are classified according to their presentation: localized-type (L-TGCT) or diffuse-type (D-TGCT). TGCT is synonymous with pigmented villonodular synovitis (PVNS). We describe the unique case of a 56-year-old obese male with type 2 diabetes who had polymicrobial septic arthritis of his left knee joint with concurrent D-TGCT in the same knee. While on a vacation, he noticed spontaneous left knee pain and swelling with an acute onset of fever. He was diagnosed with septic arthritis that was attributed to hematogenous spread from a leg laceration. The septic arthritis was treated with arthroscopic lavage and debridement, including simultaneous excision of the D-TGCT lesions, followed by intravenous ceftriaxone. Cultures of the synovial tissue that were obtained during arthroscopy grew Klebsiella oxytoca and beta-hemolytic (group B) Streptococcus agalactiae. We were not able to find another reported case of any joint with (1) a polymicrobial bacterial infection that included Klebsiella oxytoca and (2) concurrent bacterial septic arthritis and TGCT. Copyright © 2021 J. Hunter Marshall et al. DOI: 10.1155/2021/5523212 PMCID: PMC8455224